Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma.
Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma.
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DOI：
10.4103/1477-3163.76723
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发表时间：
2011-02-12
影响因子：
--
通讯作者：
Jurutka P
中科院分区：
文献类型：
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作者：
Jacobs E;Martinez ME;Buckmeier J;Lance P;May M;Jurutka P
成纤维细胞生长因子-23 （FGF-23）是一种磷酸肽，是内分泌反馈回路的关键组成部分，与激素维生素D代谢物1,25(OH)2D一起。维生素D已被证明与结直肠肿瘤呈负相关；因此，我们假设FGF-23对维生素D代谢物浓度的影响可能与结直肠肿瘤的风险有关。本研究的目的是前瞻性评估循环FGF-23浓度与异时性（复发性）结直肠腺瘤风险之间的关系。研究人员对来自熊去氧胆酸试验的100名男性和女性参与者的FGF-23水平进行了评估，其中50人患有异时性结直肠腺瘤，50人没有。与FGF-23最低分位相比，第二和第三分位的校正优势比（95% ci）分别为2.80（0.94 ~ 8.31）和3.41 (1.09 ~ 10.67)（p趋势= 0.03）。在线性回归模型中，FGF-23与1,25(OH)2D呈显著负相关（β-系数= -1.2；P=.001）。相比之下，FGF-23和25(OH)D浓度之间无统计学意义（β-系数=0.55；P= 0.10）。目前的工作提出了FGF-23与结直肠肿瘤风险之间关系的新的初步证据。FGF-23活性可能通过对个体血清和结肠1,25(OH)2D水平的生物效应介导，也可能独立于维生素D途径。为了证实和扩展这些产生假设的结果，需要在更大的人群中进行进一步的研究。
Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)2D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. The purpose of this study was to prospectively evaluate the association between circulating concentrations of FGF-23 and the risk of metachronous (recurrent) colorectal adenomas. FGF-23 levels were assessed in 100 male and female participants from the Ursodeoxycholic Acid Trial, 50 of whom had a metachronous colorectal adenoma and 50 who did not. Compared to the lowest tertile of FGF-23, the adjusted odds ratios (95% CIs) for the second and third tertiles were 2.80 (0.94 to 8.31) and 3.41 (1.09 to 10.67), respectively (P-trend=.03). In a linear regression model, there was also a statistically significant inverse relationship between FGF-23 and 1,25(OH)2D (β-coefficient=–1.2; P=.001). In contrast, no statistically significant trend was observed between FGF-23 and 25(OH)D concentrations (β-coefficient=0.55; P=.10). The current work presents novel preliminary evidence of a relationship between FGF-23 and the risk for colorectal neoplasia. FGF-23 activity may be mediated through biologic effects on individual serum and colonic 1,25(OH)2D levels, or it may be independent from the vitamin D pathway. Further studies in larger populations are necessary for confirmation and expansion of these hypothesis-generating results.