Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina
Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina
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DOI：
10.1128/aac.00324-20
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发表时间：
2020-05-01
影响因子：
4.9
通讯作者：
Ramirez, Maria Soledad
中科院分区：
文献类型：
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作者：
Adams, Mark D.;Pasteran, Fernando;Ramirez, Maria Soledad
耐碳青霉烯类不动杆菌4年监测分析阿根廷的分离株鉴定出40株携带bla（NDM-1）的菌株。基因组测序显示，大多数是鲍曼不动杆菌，而七个代表其他不动杆菌属。助理鲍曼不动杆菌基因组密切相关，表明最近传播。bla（NDM-1）定位于A.鲍曼不动杆菌菌株和非A.鲍曼不动杆菌。在部分农杆菌的质粒上发现了一个带有bla（PER-7）等抗性决定子的抗性基因岛。鲍曼不动杆菌。
A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla(NDM-1). Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla(NDM-1) was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying bla(PER-7) and other resistance determinants was found on a plasmid in some A. baumannii strains.