New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
复制标题
DOI：
10.1097/chi.0b013e31816429d3
复制
发表时间：
2008-04-01
影响因子：
13.3
通讯作者：
Faraone, Stephen V.
中科院分区：
文献类型：
--
作者：
Biederman, Joseph;Ball, Sarah W.;Faraone, Stephen V.
目的：本研究的主要目的是评估青少年和年轻成年女性注意力缺陷/多动障碍（ADHD）与重度抑郁症（MD）之间的关联。方法：受试者为患有（n = 140）和不患有（n = 122）多动症（从儿科和精神病学环境中确定）的女性。对受试者进行为期 5 年的前瞻性随访，直至青春期和成年早期，并在多个非重叠领域进行重新评估，包括精神、认知、人际、家庭和教育功能。结果：经精神科合并症调整后，患有 ADHD 的女性在青春期随访时患 MD 的风险是对照女性的 2.5 倍。与对照组女孩相比，患有 ADHD 的女性 MD 与发病年龄较早、持续时间长于两倍以上、抑郁相关损伤更严重、自杀率更高以及需要精神科住院治疗的可能性更大有关。父母的 MD 和先证者躁狂是 ADHD 女性 MD 的显着预测因子，独立于其他预测因子。结论：女性 ADHD 背景下出现的 MD 是一种损害性且严重的合并症，值得进一步的临床和科学考虑。
Objective: The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females. Method: Subjects were females with (n = 140) and without (n = 122) ADHD ascertained from pediatric and psychiatric settings. Subjects were followed prospectively for 5 years into adolescence and young adulthood and reassessed in multiple nonoverlapping domains including psychiatric, cognitive, interpersonal, family, and educational functioning. Results: Females with ADHD had a 2.5 times higher risk for MD at adolescent follow-up compared with control females, adjusting for psychiatric comorbidity. MD in females with ADHD was associated with an earlier age at onset, greater than twice the duration, more severe depression-associated impairment, a higher rate of suicidality, and a greater likelihood of requiring psychiatric hospitalization than MD in control girls. Parental MD and proband mania were significant predictors of MD among females with ADHD, independently of other predictors. Conclusions: MD emerging in the context of ADHD in females is an impairing and severe comorbidity worthy of further clinical and scientific considerations.