A novel potent tumour promoter aberrantly overexpressed in most human cancers.
A novel potent tumour promoter aberrantly overexpressed in most human cancers.
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在大多数人类癌症中，一种新型的有效肿瘤启动子异常过表达。
DOI：
10.1038/srep00015
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发表时间：
2011
影响因子：
4.6
通讯作者：
Tani, Kenzaburo
中科院分区：
文献类型：
--
作者：
Takahashi, Atsushi;Tokita, Hisashi;Takahashi, Kenzo;Takeoka, Tomoharu;Murayama, Kosho;Tomotsune, Daihachiro;Ohira, Miki;Iwamatsu, Akihiro;Ohara, Kazuaki;Yazaki, Kazufumi;Koda, Tadayuki;Nakagawara, Akira;Tani, Kenzaburo
肿瘤的复杂性和异质性阻碍了识别不同癌症之间的共性的努力。此外，由于我们对肿瘤中普遍存在的分子事件的患病率和性质的信息有限，实施分子靶向癌症筛查和预防是不可行的。在这里，我们发现Feat蛋白在大多数人类癌症中过度表达，但在正常组织中弱表达，包括睾丸、脑和肝脏。在胸腺、脾、肝和肺中异位表达FEAT的转基因小鼠自发地患上了侵袭性恶性淋巴瘤(48%，19/40)和肺转移性肝癌(肝细胞癌)(35%，14/40)，这表明FEAT蛋白在体内有效地推动了肿瘤的发生。基因表达谱显示FEAT驱动受体酪氨酸激酶和刺猬信号通路。这些发现表明，综合努力识别像FEAT一样的普遍存在的癌蛋白是有用的，并可能为具有成本效益的癌症筛查和预防提供有前途的方法。
The complexity and heterogeneity of tumours have hindered efforts to identify commonalities among different cancers. Furthermore, because we have limited information on the prevalence and nature of ubiquitous molecular events that occur in neoplasms, it is unfeasible to implement molecular-targeted cancer screening and prevention. Here, we found that the FEAT protein is overexpressed in most human cancers, but weakly expressed in normal tissues including the testis, brain, and liver. Transgenic mice that ectopically expressed FEAT in the thymus, spleen, liver, and lung spontaneously developed invasive malignant lymphoma (48%, 19/40) and lung-metastasizing liver cancer (hepatocellular carcinoma) (35%, 14/40) that models human hepatocarcinogenesis, indicating the FEAT protein potently drives tumorigenesis in vivo. Gene expression profiling suggested that FEAT drives receptor tyrosine kinase and hedgehog signalling pathways. These findings demonstrate that integrated efforts to identify FEAT-like ubiquitous oncoproteins are useful and may provide promising approaches for cost-effective cancer screening and prevention.
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影响因子：
64.5
作者：
Kim J;Woo AJ;Chu J;Snow JW;Fujiwara Y;Kim CG;Cantor AB;Orkin SH
通讯作者：
Orkin SH
DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.5
作者：
Kim, Jonghwan;Chu, Jianlin;Orkin, Stuart H.
通讯作者：
Orkin, Stuart H.
DOI：
10.1038/nrc2646
发表时间：
2009-07
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
78.5
作者：
Kufe, Donald W.
通讯作者：
Kufe, Donald W.