Changes in Anti-Mullerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years
Changes in Anti-Mullerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years
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DOI：
10.1210/jc.2010-1207
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发表时间：
2010-12-01
影响因子：
5.8
通讯作者：
Juul, A.
中科院分区：
文献类型：
--
作者：
Aksglaede, L.;Sorensen, K.;Juul, A.
背景：由未成熟的支持细胞分泌的抗苗勒管激素（AMH）可触发胎儿苗勒管的退化。AMH是一种睾丸特异性标记物，用于诊断患有生殖器模糊或双侧隐睾的婴儿。目的：本研究的目的是描述健康男性一生中AMH分泌的个体发生。背景：这是一项以健康志愿者为基础的人群研究。参与者：参与者包括1027名健康男性，从出生（脐带血）到69岁。一个亚组纵向随访至婴儿青春期[（脐带血，3个月和12个月），n = 55]，另一个组随访至青春期[（两年一次的测量），n = 83]。主要观察指标：采用灵敏免疫分析法测定血清AMH。测定血清睾酮、黄体生成素和卵泡刺激素，并对6 ~ 20岁的男孩（n = 616）进行青春期分期。结果：所有样本血清AMH均高于检出限，且根据年龄和青春期状态存在显著差异。脐带血AMH中位数为148 pmol/l，在3个月时显著升高至最高水平（P < 0.0001）。AMH在12个月时下降（P < 0.0001），并在整个儿童期保持相对稳定的水平，直到青春期，AMH逐渐下降，成人的AMH水平为婴儿水平的3-4%。结论：基于这一广泛的数据集，我们发现在所有年龄段均可检测到AMH血清水平，其中婴儿期检测到的水平最高。在青春期，AMH浓度下降，并在整个成年期保持相对稳定。AMH的潜在生理作用和AMH测量的临床适用性仍有待确定。[J] .中华内分泌杂志，2010,31(5):557 - 564。
Context: Anti-Mullerian hormone (AMH), which is secreted by immature Sertoli cells, triggers the involution of the fetal Mullerian ducts. AMH is a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism.Aim: The aim of the study was to describe the ontogeny of AMH secretion through life in healthy males.Setting: This was a population-based study of healthy volunteers.Participants: Participants included 1027 healthy males from birth (cord blood) to 69 yr. A subgroup was followed up longitudinally through the infantile minipuberty [(in cord blood, and at 3 and 12 months), n = 55] and another group through puberty [(biannual measurements), n = 83].Main Outcome Measures: Serum AMH was determined by a sensitive immunoassay. Serum testosterone, LH, and FSH were measured, and pubertal staging was performed in boys aged 6 to 20 yr (n = 616).Results: Serum AMH was above the detection limit in all samples with a marked variation according to age and pubertal status. The median AMH level in cord blood was 148 pmol/liter and increased significantly to the highest observed levels at 3 months (P < 0.0001). AMH declined at 12 months (P < 0.0001) and remained at a relatively stable level throughout childhood until puberty, when AMH declined progressively with adults exhibiting 3-4% of infant levels.Conclusion: Based on this extensive data set, we found detectable AMH serum levels at all ages, with the highest measured levels during infancy. At the time of puberty, AMH concentrations declined and remained relatively stable throughout adulthood. The potential physiological role of AMH and clinical applicability of AMH measurements remain to be determined. (J Clin Endocrinol Metab 95: 5357-5364, 2010)