The Role of miRNAs in Cartilage Homeostasis.
The Role of miRNAs in Cartilage Homeostasis.
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miRNA 在软骨稳态中的作用
DOI：
10.2174/1389202916666150817203144
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发表时间：
2015-12
期刊：
影响因子：
2.6
通讯作者：
Wei L
中科院分区：
文献类型：
--
作者：
Li YP;Wei XC;Li PC;Chen CW;Wang XH;Jiao Q;Wang DM;Wei FY;Zhang JZ;Wei L
骨关节炎（OA）是一种与年龄相关的疾病，其发病机制尚不清楚。最近的研究表明，miRNA可能在OA的发生和发展中起关键作用。我们回顾了最近的文献，并阐明了miRNA与OA软骨合成代谢和分解代谢信号之间的联系，包括四个信号通路：与软骨增殖相关的TGF-β/Smads和BMPs信号通路;与软骨增殖相关的MAPK和NF-κ B信号通路。我们还探讨了与MMP、ADAMTS和NOS（一氧化氮合酶）家族以及分解代谢细胞因子IL-1和TNF-α的关系。讨论了miRNAs在软骨变性、软骨细胞增殖和分化等生物学过程中的潜在作用。集体证据表明，miRNA在软骨退变中起关键作用。这些发现将有助于理解控制关节软骨稳态的分子网络，并阐明miRNA在OA发病机制中的作用。
Osteoarthritis (OA) is an age-related disease with poorly understood pathogenesis. Recent studies have demonstrated that miRNA might play a key role in OA initiation and development. We reviewed recent publications and elucidated the connection between miRNA and OA cartilage anabolic and catabolic signals, including four signaling pathways: TGF-β/Smads and BMPs signaling, associated with cartilage anabolism; and MAPK and NF-KB signaling, associated with cartilage catabolism. We also explored the relationships with MMP, ADAMTS and NOS (NitricOxide Synthases) families, as well as with the catabolic cytokines IL-1 and TNF-α. The potential role of miRNAs in biological processes such as cartilage degeneration, chondrocyte proliferation, and differentiation is discussed. Collective evidence indicates that miRNAs play a critical role in cartilage degeneration. These findings will aid in understanding the molecular network that governs articular cartilage homeostasis and in to elucidate the role of miRNA in the pathogenesis of OA.