Presence of INF γ-secreting lymphocytes specific to prostate antigens in a group of chronic prostatitis patients
Presence of INF γ-secreting lymphocytes specific to prostate antigens in a group of chronic prostatitis patients
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DOI：
10.1016/j.clim.2005.03.011
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发表时间：
2005-08-01
影响因子：
8.6
通讯作者：
Rivero, VE
中科院分区：
文献类型：
--
作者：
Motrich, RD;Maccioni, M;Rivero, VE
急性和慢性感染前列腺炎是最好的了解前列腺综合征，但他们是最不常见的。相比之下，尽管慢性非感染性前列腺炎是最常见的综合征，但其病因已被证明是难以捉摸的，尽管多年的调查。在本研究中，我们分析了一组感染性和非感染性慢性前列腺炎患者，以寻找前列腺抗原可能存在的自身免疫反应。我们证明淋巴细胞的存在能够增殖的反应已知的人类前列腺抗原，如PSA和PAP仅在一组非感染性慢性前列腺炎患者。我们观察到，与其他自身免疫性疾病一样，针对两种或多种自身抗原的增殖性反应是一个共同特征。此外，当在培养上清液中测量INF- γ和IL-10水平时，仅在前列腺抗原增殖反应阳性的患者样本中检测到INF- γ水平显著升高。有趣的是，只有这些患者的血清中炎性细胞因子（IL-1和tnf - α）水平显著升高，表明这是一种非感染性的局部炎症。我们的研究结果表明，在34%的慢性非感染性前列腺炎患者中检测到前列腺抗原特异性分泌INF - γ淋巴细胞。我们推测这些细胞可能参与了前列腺的炎症过程，从而改变了前列腺的生物学功能。(c) 2005爱思唯尔公司版权所有。
Acute and chronic infections prostatitis are the best understood of the prostate syndromes, but they are the least frequent. In contrast, although chronic non-infectious prostatitis is the most frequent syndrome, its cause has proved elusive despite years of investigation. In the present study we analyzed a group of patients with infectious and non-infectious chronic prostatitis in order to search for the presence of a possible autoimmune response to prostate antigens. We demonstrated the presence of lymphocytes able to proliferate in response to known human prostate antigens such as PSA and PAP only in a group of patients with non-infectious chronic prostatitis. We observed that, as in other autoimmune diseases, a proliferative response against two or more autoantigens was a common feature. Moreover, when INF-gamma and IL-10 levels were measured in culture supernatants, significantly elevated levels of INF gamma were detected only in samples from patients with positive proliferative response to prostate antigens. Interestingly, only these patients showed significantly elevated levels of inflammatory cytokines (IL-1 and TNF-alpha) in serninal plasma, arguing for a local inflammation of non-infectious cause. Our results show that INF gamma-secreting lymphocytes specific to prostate antigens are in fact detected in 34% of the patients with chronic non-infectious prostatitis. We speculate that these cells could be involved in the inflammatory process taking place in the prostate gland and therefore could alter its biological function. (c) 2005 Elsevier Inc. All rights reserved.