TRPA1 Agonists-Allyl Isothiocyanate and Cinnamaldehyde-Induce Adrenaline Secretion
TRPA1 Agonists-Allyl Isothiocyanate and Cinnamaldehyde-Induce Adrenaline Secretion
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DOI：
10.1271/bbb.80289
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发表时间：
2008-10-01
影响因子：
1.6
通讯作者：
Watanabe, Tatsuo
中科院分区：
文献类型：
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作者：
Iwasaki, Yusaku;Tanabe, Manabu;Watanabe, Tatsuo
温度敏感的瞬时受体电位(Trp)通道，特别是TRPV1和TRPA1，被香料中存在的刺激性化合物激活。辣椒中的刺激物辣椒素可激活TRPV1，诱导肾上腺素分泌，增加能量消耗。TRPV1主要在感觉神经元表达，并与dTRPA1高频共表达。然而，TRPA1激动剂如异硫氰酸烯丙酯(AITC)和肉桂醛(CNA)等芥末和肉桂中的刺激性成分分泌肾上腺素的机制尚不清楚。我们观察了AITC和CNA对麻醉大鼠肾上腺素分泌的影响。静脉注射AITC或CNA(10 mg/kg)可增加肾上腺素的分泌。这些反应在辣椒素处理的大鼠中完全消失，传感器受损。)，神经功能。此外，胆碱能阻滞剂(六甲溴铵和阿托品)可减弱AITC或CNA诱导的肾上腺素分泌。这些结果表明，TRPA1激动剂通过中枢神经系统激活感觉神经并诱导肾上腺素分泌。
Thermosensitive transient receptor potential (TRP) channels, especially TRPV1 and TRPA1, are activated fly the pungent compounds present in spices. TRPV1 activation by the intake of capsaicin, the irritant in hot pepper, induces adrenaline secretion and increases energy consumption. TRPV1 is mainly expressed in the sensory neurons and coexpressed with dTRPA1 at a high frequency. However, the mechanism underlying adrenaline secretion by TRPA1 agonists such as allyl isothiocyanate (AITC) and cinnamaldehyde (CNA), the pungent ingredients in mustard and cinnamon, is not known. We examined whether AITC and CNA could induce adrenaline secretion in anesthetized rats. An intravenous injection of AITC or CNA (10 mg/kg) increased adrenaline secretion. These responses disappeared completely in capsaicin-treated rats with an impaired sensor.), nerve function. Moreover, pretreatment with cholinergic blockers (hexamethonium and atropine) attenuated the AITC- or CNA-induced adrenaline secretion. These results suggest that TRPA1 agonists activate the sensory nerves and induce adrenaline secretion via the central nervous system.