The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement - A pilot study
The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement - A pilot study
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DOI：
10.1097/01.blo.0000143556.41472.2a
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发表时间：
2004-10-01
影响因子：
4.2
通讯作者：
DeClerk, GR
中科院分区：
文献类型：
--
作者：
McLaren, AC;Nelson, CL;DeClerk, GR
抗生素从丙烯酸骨水泥(聚甲基丙烯酸甲酯[PMMA])中的洗脱依赖于液体进入含有抗生素的骨水泥的深处。商业上制备的多孔抗生素微珠的洗脱率高于手工混合的非多孔抗生素PMMA混合物。为了提高庆大霉素从手混型PMMA中的洗脱率，添加甘氨酸作为填充剂以产生孔洞。庆大霉素从抗生素PMMA-甘氨酸混合物中的洗脱量随着甘氨酸用量的增加而增加。每批Palacos PMMA含有3.6克庆大霉素粉末和14克结晶甘氨酸，在2天内从PMMA中洗脱庆大霉素，与之前报道的从商业制备的多孔Septopal PMMA微珠中洗脱庆大霉素相似。随着进一步的研究，有可能确定一种特定的填充物和一定体积的填充物，可以手工混合到抗生素PMMA中，以产生特定临床要求所需的洗脱行为。
Elution of antibiotics from acrylic bone cement (polymethylmethacrylate [PMMA]) is dependent on the access of fluid to the depths of the cement that contains the antibiotic. Commercially prepared antibiotic beads that are porous have higher elution rates than hand-mixed, nonporous antibiotic PMMA mixtures. To increase the elution of gentamicin from hand-mixed PMMA, glycine was added as a filler to produce porosity. Elution of gentamicin from the antibiotic PMMA-glycine mixture increased with increasing amounts of glycine. With 3.6 g gentamicin powder and 14 g of crystalline glycine per batch of Palacos PMMA, the elution of gentamicin from the PMMA at 2 days was, similar to the previously documented elution of gentamicin from commercially prepared porous Septopal PMMA beads. With further investigation it may be possible to identify a specific filler and a volume of filler that can be hand mixed in antibiotic PMMA to produce the elution behavior that is needed for specific clinical requirements.