Asbestos inhalation and the induction of splenic lymphocytic proliferation in the rat.
Asbestos inhalation and the induction of splenic lymphocytic proliferation in the rat.
复制标题
石棉吸入和大鼠脾淋巴细胞增殖的诱导。
作者：
E. Kagan;K. Miller
有证据表明，肺泡巨噬细胞在石棉肺的发病机制中起着关键作用，因为这种吞噬细胞是这种疾病中逐渐形成的病变的重要组成部分。1我们最近证明，从石棉暴露大鼠中获得的肺泡巨噬细胞可以在体外培养过程中与自体富含T细胞的脾淋巴细胞产生稳定的物理相互作用。2这种相互作用显示有两个组成部分：一种类似于通过使巨噬细胞经受偏高碘酸钠（Na 104）3的过氧化作用而产生的效应，以及一种类似于巨噬细胞周围的淋巴细胞的抗原定向聚集的效应。4作为先前研究的延伸，我们现在报告从石棉暴露的大鼠获得的肺泡巨噬细胞可以在体外引发强烈的脾淋巴细胞增殖反应。
T here is evidence that the alveolar macrophage plays a critical role in the pathogenesis of asbestosis, since this phagocytic cell is an important component of evolving lesions in this disease.1 We have recently demonstrated that alveolar macrophages obtained from asbestos-exposed rats can evoke a stabilized physical interaction during in vitro culture with autologous T cell-enriched splenic lymphocytes.2 This interaction was shown to have two components: an effect analogous to that produced by subjecting macrophages to the peroxidant action of sodium metaperiodate (Na104)3 and an effect which was similar to antigendirected clustering of lymphocytes around macrophages.4 As an extension of the previous study we now report that alveolar macrophages obtained from asbestos-exposed rats can initiate a vigorous in vitro splemc lymphocyte proliferative response.