What Clonal Hematopoiesis Can Teach Us About MDS.
What Clonal Hematopoiesis Can Teach Us About MDS.
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DOI：
10.3389/fonc.2022.794021
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发表时间：
2022
影响因子：
4.7
通讯作者：
Bolton KL
中科院分区：
文献类型：
--
作者：
Chan ICC;Wiley BJ;Bolton KL
克隆造血（CH）被定义为突变的造血干细胞和祖细胞（HSPC）的克隆扩增，是一种常见的衰老过程。 CH 是发生血液系统恶性肿瘤的危险因素，最常见的是髓系肿瘤 (MN)，包括急性髓系白血病 (AML)、骨髓增生异常综合征 (MDS) 和骨髓增殖性肿瘤 (MPN)。最近的工作阐明了 CH 的发育和细胞适应性如何受到衰老、环境暴露和个体种系（遗传）遗传背景的影响。这反过来又为包括 MDS 在内的 MN 发病机制提供了宝贵的见解。在这篇综述中，我们讨论了 CH 的遗传起源、影响 CH 的环境压力因素以及 CH 对包括 MDS 在内的健康结果的影响。由于 MN 具有共同的风险因素和基础生物学，因此我们关于 CH 影响的大部分讨论一般都围绕着 MN，而不是专门关注 MDS。我们总结了未来的方向和研究领域，包括 CH 的干预研究如何为未来的 MN 治疗方法（包括 MDS）提供信息。
Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem and progenitor cells (HSPCs), is a common aging process. CH is a risk factor for the development of hematologic malignancies, most commonly myeloid neoplasms (MNs) including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasm (MPN). Recent work has elucidated how the development and cellular fitness of CH is shaped by aging, environmental exposures, and the germline (inherited) genetic background of an individual. This in turn has provided valuable insights into the pathogenesis of MNs including MDS. Here, in this review, we discuss the genetic origins of CH, the environmental stressors that influence CH, and the implications of CH on health outcomes including MDS. Since MNs have shared risk factors and underlying biology, most of our discussion regarding the implications of CH surrounds MN in general rather than focusing specifically on MDS. We conclude with future directions and areas of investigation including how intervention studies of CH might inform future therapeutic approaches to MN including MDS.
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影响因子：
64.8
作者：
Bick AG;Weinstock JS;Nandakumar SK;Fulco CP;Bao EL;Zekavat SM;Szeto MD;Liao X;Leventhal MJ;Nasser J;Chang K;Laurie C;Burugula BB;Gibson CJ;Lin AE;Taub MA;Aguet F;Ardlie K;Mitchell BD;Barnes KC;Moscati A;Fornage M;Redline S;Psaty BM;Silverman EK;Weiss ST;Palmer ND;Vasan RS;Burchard EG;Kardia SLR;He J;Kaplan RC;Smith NL;Arnett DK;Schwartz DA;Correa A;de Andrade M;Guo X;Konkle BA;Custer B;Peralta JM;Gui H;Meyers DA;McGarvey ST;Chen IY;Shoemaker MB;Peyser PA;Broome JG;Gogarten SM;Wang FF;Wong Q;Montasser ME;Daya M;Kenny EE;North KE;Launer LJ;Cade BE;Bis JC;Cho MH;Lasky-Su J;Bowden DW;Cupples LA;Mak ACY;Becker LC;Smith JA;Kelly TN;Aslibekyan S;Heckbert SR;Tiwari HK;Yang IV;Heit JA;Lubitz SA;Johnsen JM;Curran JE;Wenzel SE;Weeks DE;Rao DC;Darbar D;Moon JY;Tracy RP;Buth EJ;Rafaels N;Loos RJF;Durda P;Liu Y;Hou L;Lee J;Kachroo P;Freedman BI;Levy D;Bielak LF;Hixson JE;Floyd JS;Whitsel EA;Ellinor PT;Irvin MR;Fingerlin TE;Raffield LM;Armasu SM;Wheeler MM;Sabino EC;Blangero J;Williams LK;Levy BD;Sheu WH;Roden DM;Boerwinkle E;Manson JE;Mathias RA;Desai P;Taylor KD;Johnson AD;NHLBI Trans-Omics for Precision Medicine Consortium;Auer PL;Kooperberg C;Laurie CC;Blackwell TW;Smith AV;Zhao H;Lange E;Lange L;Rich SS;Rotter JI;Wilson JG;Scheet P;Kitzman JO;Lander ES;Engreitz JM;Ebert BL;Reiner AP;Jaiswal S;Abecasis G;Sankaran VG;Kathiresan S;Natarajan P
通讯作者：
Natarajan P
DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
影响因子：
45.3
作者：
Kristinsson, Sigurdur Y.;Bjorkholm, Magnus;Goldin, Lynn R.
通讯作者：
Goldin, Lynn R.
影响因子：
64.8
作者：
Busch, Katrin;Klapproth, Kay;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer
影响因子：
11.4
作者：
Dawoud, Ahmed A. Z.;Tapper, William J.;Cross, Nicholas C. P.
通讯作者：
Cross, Nicholas C. P.