SOMATIC CHROMOSOME ABERRATIONS INDUCED BY HUMAN WHOLE-BODY IRRADIATION - RECUPLEX CRITICALITY ACCIDENT
SOMATIC CHROMOSOME ABERRATIONS INDUCED BY HUMAN WHOLE-BODY IRRADIATION - RECUPLEX CRITICALITY ACCIDENT
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DOI：
10.2307/3572080
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发表时间：
1966-01-01
影响因子：
3.4
通讯作者：
GOOCH, PC
中科院分区：
文献类型：
--
作者：
BENDER, MA;GOOCH, PC
1962年4月7日发生在华盛顿汉福德[美国]的Recuplex临界事故期间，从3名暴露于急性、全身、混合γ射线和裂变中子辐射的男性中定期获得外周血白细胞染色体畸变频率。第一批样品在辐照后4小时采集，其余样品在随后2年内间隔采集。物理剂量估计值范围从12拉德到47拉德。在所有3名男性的第1份样本中均观察到预期类型的染色体畸变。虽然畸变产率低，但其频率与基于剂量估计值和畸变产生系数的预期一致，畸变产生系数是通过体外用X射线和裂变中子照射全血样品确定的。在急性全身照射的情况下，染色体畸变频率的测量似乎是一种实用的生物剂量测定方法;尽管与物理剂量估计值的绝对一致性可能并不完美，特别是在非常低的剂量下，但该方法提供了对生物效应的快速“粗略”估计。有效的估计可以从白细胞样本获得许多天，也许几个星期后，照射。畸变频率在几周后下降，但在2年样本中仍观察到一些畸变。
Frequency of chromosome aberrations in peripheral leukocytes obtained periodically from 3 men exposed to acute, whole-body, mixed 7-ray and fission-neutron radiation during the Recuplex criticality accident which occurred on April 7, 1962, at Hanford, Washington [USA]. The 1st samples were obtained 4 hr. after the irradiations, and the rest at intervals over the following 2 years. Physical dose estimates ranged from 12 rads to 47 rads. Chromosome aberrations of the expected types were seen in the 1st samples from all 3 men. Although the aberration yields were low, their frequencies are consistent with expectations based on the dose estimates and the coefficients of aberration production which have been determined by irradiation of whole-blood samples in vitro with X-rays and with fission neutrons. Measurement of chromosome aberration frequencies seems a practical method of biological dosimetry in the case of acute, whole-body exposures; although absolute agreement with physical dose estimates may not be perfect, expecially at very low doses, the method offers a quick "ball park" estimate on biological effect. Valid estimates may be made from leukocyte samples obtained many days, and perhaps weeks, after irradiation. Frequencies of aberrations dropped after several weeks, but some aberrations were still seen in the 2-year samples.