Physical co-morbidity among treatment resistant vs. treatment responsive patients with major depressive disorder
Physical co-morbidity among treatment resistant vs. treatment responsive patients with major depressive disorder
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DOI：
10.1016/j.euroneuro.2012.09.002
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发表时间：
2013-08-01
影响因子：
5.6
通讯作者：
Zohar, J.
中科院分区：
文献类型：
--
作者：
Amital, D.;Fostick, L.;Zohar, J.
在导致严重抑郁障碍患者治疗抵抗的因素中，共病的躯体疾病被认为起着重要作用。在目前的研究中，我们比较了ICD-10定义的702名严重抑郁障碍患者的多中心大样本的身体共患病率。共有356名参与者被定义为难治性抑郁症(TRD)患者--他们没有通过两项或两项以上足够的抗抑郁药物试验。在TRD参与者和非TRD参与者之间，没有发现任何ICD-10类别的患病率有显著差异。这一发现表明，尽管糖尿病、甲状腺功能障碍、高血压、缺血性心脏病和消化系统疾病等身体状况常常伴随着并存的MOD，但它们不一定对MOD的病程或治疗反应的可能性有影响。在TRD参与者中，发现乳腺癌、偏头痛和青光眼的共病比率略高。对这些发现的可能解释及其与TRD的可能关系进行了讨论。(C)2012年爱思唯尔和ECNP。版权所有。
Co-morbid physical illness has been suggested to play an important role among the factors contributing to treatment resistance in patients with major depressive disorder. In the current study we compared the rate of physical co-morbidity, defined by ICD-10, among a large multicenter sample of 702 patients with major depressive disorder. A total of 356 of the participants were defined as treatment resistant depression (TRD) patients-having failed two or more adequate antidepressant trials. No significant difference was found between TRD and non-TRD participants in the prevalence of any ICD-10 category. This finding suggests that although physical conditions such as diabetes, thyroid dysfunction, hypertension, ischemic heart disease, and peptic diseases are often accompanied by co-morbid MOD, they do not necessarily have an impact on the course of MOD or the likelihood to respond to treatment. Marginally higher rates of co-morbid breast cancer, migraine and glaucoma were found among TRD participants. Possible explanations for these findings and their possible relation to TRD are discussed. (C) 2012 Elsevier B.V. and ECNP. All rights reserved.