Regulatory immunotherapy in bone marrow transplantation.
Regulatory immunotherapy in bone marrow transplantation.
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骨髓移植中的调节性免疫治疗。
DOI：
10.1100/2011/768948
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发表时间：
2011
影响因子：
--
通讯作者：
Pillai,Asha
中科院分区：
文献类型：
--
作者：
Morales-Tirado,Vanessa;Luszczek,Wioleta;vanderMerwe,Marie;Pillai,Asha
每年都有个体接受造血干细胞移植（HSCT）以根除恶性和非恶性疾病。同种异体移植的免疫生物学是一个不断发现的领域，从移植前受体的预处理到负责移植、移植物抗宿主病和移植物抗肿瘤效应的供体细胞群。在这篇综述中，我们重点介绍了供体型免疫调节性T细胞，即自然杀伤T细胞（NKT）和调节性T细胞（Treg），以及它们在同种异体HSCT后耐受诱导中的当前和潜在作用。
Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient′s conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft‐versus‐host disease, and graft‐versus‐tumor effect. In this review, we focus on donor‐type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.