Temporal aspects of the electroretinogram in diabetic retinopathy.
Temporal aspects of the electroretinogram in diabetic retinopathy.
复制标题
DOI：
10.1001/archopht.1987.01060050078042
复制
发表时间：
1987-05
影响因子：
--
通讯作者：
G. Bresnick;M. Palta
中科院分区：
文献类型：
--
作者：
G. Bresnick;M. Palta
我们测量了72例糖尿病患者和29例对照组的视网膜电图的几个组成部分的时间方面。测量包括由明亮闪光刺激引起的a波和振荡电位的隐式时间和响应于30 Hz闪烁光的B波的隐式时间。与对照组相比，糖尿病患者的a波和前三个振荡电位节点明显延迟;在糖尿病患者中，第二和第三个节点的延迟显著增加，这是视网膜病变严重程度增加的函数。同样，糖尿病患者的30 Hz闪烁隐式时间（有和没有背景光）显著延迟，延迟的幅度随着视网膜病变严重程度的增加而增加。30 Hz闪烁隐式时间与视网膜病变严重程度的相关性在彩色眼底照片中分级的视网膜病变水平以及在荧光素血管造影中分级的视网膜毛细血管无灌注和渗漏中具有显著性。比较15例患者的30 Hz闪烁隐式时间，其中一只眼接受全视网膜激光光凝治疗，另一只眼未接受治疗（治疗随机分配），显示治疗眼与未治疗眼相比有显著延迟（配对眼比较）。这表明，全视网膜激光光凝诱导治疗糖尿病视网膜病变的眼睛的b波隐式时间进一步延迟。
We measured the temporal aspects of several components of the electroretinogram in 72 patients with diabetes and 29 control subjects. The measurements consisted of the implicit times of the a wave and oscillatory potentials elicited by a bright-flash stimulus and the implicit time of the b wave in response to a 30-Hz flickering light. The a wave and first three oscillatory potential nodes were significantly delayed in the patients with diabetes compared with the controls; among the diabetics, a significant increase in the delay of the second and third nodes occurred as a function of increasing retinopathy severity. Similarly, the 30-Hz flicker implicit times (with and without a background light) were significantly delayed in patients with diabetes, and the magnitude of the delay increased with increasing retinopathy severity. The correlations of 30-Hz flicker implicit times with retinopathy severity were significant for retinopathy level graded in color fundus photographs as well as for retinal capillary nonperfusion and leakage graded in fluorescein angiograms. A comparison of 30-Hz flicker implicit times in 15 patients with one eye treated with panretinal laser photocoagulation and the other eye untreated (treatment was randomly assigned) showed a significant delay in the treated eyes compared with the untreated eyes (paired eye comparison). This suggests that panretinal laser photocoagulation induces a further delay in the b-wave implicit times of eyes treated for diabetic retinopathy.