Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer
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DOI：
10.1096/fj.10-167304
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发表时间：
2011-02-01
期刊：
影响因子：
4.8
通讯作者：
Ghosh, Pradipta
中科院分区：
文献类型：
--
作者：
Garcia-Marcos, Mikel;Jung, Barbara H.;Ghosh, Pradipta
转移占癌症相关死亡的大多数。准确预测肿瘤的转移潜力一直是难以捉摸的，并且对临床上有用的标记物的搜索仍在继续。我们先前报道GIV/Girdin通过激活G α i的C-末端鸟嘌呤-核苷酸交换因子基序触发肿瘤细胞迁移。在这里，我们确定GIV作为一种转移相关蛋白，其全长转录本（GIV-fl）仅在高度侵袭性的结肠癌、乳腺癌和胰腺癌细胞中表达，而不在其侵袭性差的对应细胞中表达。对56名II期结直肠癌患者的队列进行的前瞻性、探索性生物标志物研究揭示了肿瘤上皮中GIV-fl表达与缩短的无转移生存期之间的显著相关性。与GIV-fl阴性肿瘤患者相比，GIV-fl阳性肿瘤患者的生存率显著降低[P
Metastasis accounts for the majority of cancer-related deaths. Accurate prediction of metastatic potential of tumors has been elusive, and the search for clinically useful markers continues. We previously reported that GIV/Girdin triggers tumor cell migration by virtue of a C-terminal guanine-nucleotide exchange factor motif that activates G alpha i. Here we identify GIV as a metastasis-related protein whose full-length transcript (GIV-fl) is expressed exclusively in highly invasive colon, breast, and pancreatic carcinoma cells and not in their poorly invasive counterparts. A prospective, exploratory biomarker study conducted on a cohort of 56 patients with stage II colorectal cancer revealed a significant correlation between GIV-fl expression in tumor epithelium and shortened metastasis-free survival. Survival rate for patients with GIV-fl-positive tumors is significantly reduced compared with the patients with GIV-fl-negative tumors [P