CREATINE SUPPLEMENTATION DECREASES OXIDATIVE DNA DAMAGE AND LIPID PEROXIDATION INDUCED BY A SINGLE BOUT OF RESISTANCE EXERCISE
CREATINE SUPPLEMENTATION DECREASES OXIDATIVE DNA DAMAGE AND LIPID PEROXIDATION INDUCED BY A SINGLE BOUT OF RESISTANCE EXERCISE
复制标题
DOI：
10.1519/jsc.0b013e3182162f2b
复制
发表时间：
2011-12-01
影响因子：
3.2
通讯作者：
Rahimi, Rahman
中科院分区：
文献类型：
--
作者：
Rahimi, Rahman
拉希米河补充肌酸可降低单次抗阻运动引起的DNA氧化损伤和脂质过氧化反应。J Strength Cond Res 25（12）：3448-3455，2011-肌酸（Cr）或甲基胍-乙酸可以从外源性来源（如鱼或肉）摄入，或由身体内源性产生，主要在肝脏中。它被用来作为一个ergogenic援助，以提高肌肉质量，力量和耐力。因此，铬的积极治疗效益在各种氧化应激相关的疾病已在文献中报道，最近，铬也已被证明发挥直接的抗氧化作用。因此，本研究的目的是探讨急性抗阻运动（RE）对男性运动员氧化应激反应和氧化DNA损伤的影响，以及补充铬是否可以消除任何观察到的差异。27名接受抗阻训练的男性被随机分为铬补充组（铬组[21.6 +/- 3.6岁]，每天服用4 x 5 g一水铬）或安慰剂（PL）补充组（PL组[21.2 +/- 3.2岁]，每天服用4 x 5 g麦芽糊精）。采用双盲研究设计，为期7天的补充期。在补充的第七天之前和之后，受试者以平金字塔负荷模式进行RE方案（7组，每组4次，最大重复次数为60-90 1）。在运动前、运动后即刻和运动后24小时采集血液和尿液样本，分析血浆丙二醛（MDA）和尿8-羟基-2-脱氧鸟苷（8-OHdG）排泄。在补充期之前，RE后观察到尿8-OHdG排泄和血浆MDA水平显著增加。补充铬可显著提高运动成绩，并减弱尿8-OHdG排泄和血浆MDA的变化。这些结果表明，铬补充减少氧化DNA损伤和脂质过氧化反应引起的一个单一的回合的RE。
Rahimi, R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. J Strength Cond Res 25(12): 3448-3455, 2011-Creatine (Cr), or methyl guanidine-acetic acid, can be either ingested from exogenous sources, such as fish or meat, or produced endogenously by the body, primarily in the liver. It is used as an ergogenic aid to improve muscle mass, strength, and endurance. Heretofore, Cr's positive therapeutic benefits in various oxidative stress-associated diseases have been reported in the literature and, recently, Cr has also been shown to exert direct antioxidant effects. Therefore, the purpose of this study was to investigate the effects of an acute bout of resistance exercise (RE) on oxidative stress response and oxidative DNA damage in male athletes and whether supplementation with Cr could negate any observed differences. Twenty-seven resistance-trained men were randomly divided into a Cr supplementation group (the Cr group [21.6 +/- 3.6 years], taking 4 x 5 g Cr monohydrate per day) or a placebo (PL) supplementation group (the PL group [21.2 +/- 3.2 years], taking 4 x 5 g maltodextrin per day). A double-blind research design was employed for a 7-day supplementation period. Before and after the seventh day of supplementation, the subjects performed an RE protocol (7 sets of 4 exercises using 60-90 1 repetition maximum) in the flat pyramid loading pattern. Blood and urine samples taken before, immediately, and 24-hour postexercise were analyzed for plasma malondialdehyde (MDA) and urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) excretion. Before the supplementation period, a significant increase in the urinary 8-OHdG excretion and plasma MDA levels was observed after RE. The Cr supplementation induces a significant increase in athletics performance, and it attenuated the changes observed in the urinary 8-OHdG excretion and plasma MDA. These results indicate that Cr supplementation reduced oxidative DNA damage and lipid peroxidation induced by a single bout of RE.