Basolateral membrane Na+/H+ antiport, Na+/base cotransport, and Na+-independent Cl-/base exchange in the rabbit S3 proximal tubule.
Basolateral membrane Na+/H+ antiport, Na+/base cotransport, and Na+-independent Cl-/base exchange in the rabbit S3 proximal tubule.
复制标题
兔 S3 近曲小管中的基底外侧膜 Na /H 逆向转运、Na /碱基共转运和 Na 不依赖的 Cl-/碱基交换。
DOI：
10.1172/jci113925
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
I. Kurtz
中科院分区：
文献类型：
--
作者：
I. Kurtz
The basolateral membrane Na+ and Cl(-)-dependent acid-base transport processes were studied in the isolated perfused rabbit S3 proximal straight tubule. Intracellular pH (pHi) was measured with 2'7'-biscarboxyethyl-5,6-carboxyfluorescein (BCECF) and a microfluorometer coupled to the tubule perfusion apparatus. Reduction of basolateral HCO3- from 25 to 5 mM caused pHi to decrease at a rate of 0.81 pH/min. Approximately 50% of this rate was Na+-dependent, 30% Cl(-)-dependent and 20% Na+ and Cl(-)-independent. Two basolateral Na+-dependent acid base transport pathways were detected: (a) an amiloride-sensitive Na+/H+ antiporter and (b) a stilbene-sensitive Na+/base cotransporter. No evidence was found for a Na+-dependent Cl-/base exchanger. The Cl(-)-dependent component of basolateral base efflux was mediated by a stilbene-sensitive Na+-independent Cl-/base exchange pathway. The results suggest that the acid base transport pathways of the basolateral membrane of the S3 proximal tubule differ from more proximal nephron segments.
影响因子：
--
作者：
KINSELLA, JL;ARONSON, PS
通讯作者：
ARONSON, PS
DOI：
10.1016/s0021-9258(19)84448-4
发表时间：
1986-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
S. Grassl;P. Aronson
通讯作者：
S. Grassl;P. Aronson
NH3 和 NH4 通过兔肾近端直管转运。
DOI：
10.1152/ajprenal.1987.252.2.f232
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Garvin,JL;Burg,MB;Knepper,MA
通讯作者：
Knepper,MA