Beliefs in vaccine as causes of autism among SPARK cohort caregivers.
Beliefs in vaccine as causes of autism among SPARK cohort caregivers.
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DOI：
10.1016/j.vaccine.2019.12.026
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发表时间：
2020-02-11
期刊：
影响因子：
5.5
通讯作者：
O'Roak, Brian J.
中科院分区：
文献类型：
--
作者：
Fombonne, Eric;Goin-Kochel, Robin P.;O'Roak, Brian J.
关键词：
对自闭症的恐惧导致儿童免疫接种率下降，并导致可预防的传染病死灰复燃。识别那些相信自闭症谱系障碍（ASD）疫苗在其孩子中的因果作用的父母的特征可能有助于针对教育活动并提高对免疫接种计划的遵守。比较同意或不同意疫苗在自闭症中发挥病因作用的ASD儿童的照顾者的1）社会人口统计学特征和2）儿童的发育和临床特征。来自16，525名18岁以下ASD参与者的数据来自SPARK，这是一项始于2016年的国家研究队列。护理人员在登记时完成了问卷调查，其中包括关于儿童免疫接种和ASD其他因素的病因作用的信念问题。有关家庭社会人口特征、孤独症首发症状、发育退化、合并精神疾病、癫痫发作和当前功能水平的数据可用。ASD患者中男性占80.4%，平均年龄为8.1岁（SD = 4.1）。总体而言，16.5%的照顾者认可免疫接种是自闭症的感知原因。与不同意疫苗是ASD原因的护理人员相比，那些相信疫苗因果关系的人不成比例地来自少数民族，受教育程度较低和不富裕的背景。他们的孩子更经常经历涉及语言和其他技能的发育退化，被诊断得更早，在生命的第二年失去了技能，并且语言，适应性和认知结果更差。参加国家研究队列的六分之一的照顾者认为，儿童免疫接种可能是他们孩子自闭症的原因。父母的社会背景（非白人，受教育程度较低）和儿童的发展特征（第二年的回归，较差的语言技能和较差的适应性结果）指数照顾者谁更有可能怀有这些信念，并可能受益于有针对性的教育活动。
Fear of autism has led to a decline in childhood-immunization uptake and to a resurgence of preventable infectious diseases. Identifying characteristics of parents who believe in a causal role of vaccines for autism spectrum disorder (ASD) in their child may help targeting educational activities and improve adherence to the immunization schedule. To compare caregivers of children with ASD who agree or disagree that vaccines play an etiological role in autism for 1) socio-demographics characteristics and 2) developmental and clinical profiles of their children. Data from 16,525 participants with ASD under age 18 were obtained from SPARK, a national research cohort started in 2016. Caregivers completed questionnaires at registration that included questions on beliefs about the etiologic role of childhood immunizations and other factors in ASD. Data were available about family socio-demographic characteristics, first symptoms of autism, developmental regression, co-occurring psychiatric disorders, seizures, and current levels of functioning. Participants with ASD were 80.4% male with a mean age of 8.1 years (SD = 4.1). Overall, 16.5% of caregivers endorsed immunizations as perceived causes of autism. Compared to caregivers who disagreed with vaccines as a cause for ASD, those who believed in vaccine causation came disproportionately from ethnic minority, less educated, and less wealthy backgrounds. More often their children had experienced developmental regression involving language and other skills, were diagnosed earlier, had lost skills during the second year of life, and had worse language, adaptive, and cognitive outcomes. One in six caregivers who participate in a national research cohort believe that child immunizations could be a cause of autism in their child. Parent social background (non-White, less educated) and child developmental features (regression in second year, poorer language skills, and worse adaptive outcomes) index caregivers who are more likely to harbor these beliefs and could benefit from targeted educational activities.
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影响因子：
3.9
作者：
Goin-Kochel RP;Trinh S;Barber S;Bernier R
通讯作者：
Bernier R
影响因子：
2.5
作者：
Goin-Kochel, Robin P.;Esler, Amy N.;Hus, Vanessa
通讯作者：
Hus, Vanessa
影响因子：
8
作者：
Kogan, Michael D.;Vladutiu, Catherine J.;Lu, Michael C.
通讯作者：
Lu, Michael C.
影响因子：
8
作者：
Nyhan, Brendan;Reifler, Jason;Freed, Gary L.
通讯作者：
Freed, Gary L.
DOI：
10.1111/j.1365-2788.2008.01134.x
发表时间：
2009-02-01
影响因子：
3.6
作者：
Meilleur, A. -A. S.;Fombonne, E.
通讯作者：
Fombonne, E.