Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
复制标题
作者：
Feldman AM;She L;McNamara DM;Mann DL;Bristow MR;Maisel AS;Wagner DR;Andersson B;Chiariello L;Hayward CS;Hendry P;Parker JD;Racine N;Selzman CH;Senni M;Stepinska J;Zembala M;Rouleau J;Velazquez EJ;Lee KL
We evaluated the ability of 23 genetic variants to provide prognostic information in patients enrolled in the Genotype Sub-studies of the Surgical Treatment for Ischemic Heart Failure (STICH) trials. Patients in STICH Hypothesis 1 were randomized to medical therapy with or without CABG (Coronary Artery Bypass Grafting). Those in STICH Hypothesis 2 were randomized to CABG or CABG with left ventricular reconstruction. In patients assigned to STICH Hypothesis 2 (n=714), no genetic variant met the pre-specified Bonferroni-adjusted threshold for statistical significance (p<0.002); however, several met nominal prognostic significance: variants in the β2-adrenergic receptor gene (β2-AR Gln27Glu) and in the A1-adenosine receptor gene (A1-717 T/G) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem (p=0.027 and 0.031, respectively). These relationships remained nominally significant even after multivariable adjustment for prognostic clinical variables. However, none of the 23 genetic variants influenced all-cause mortality or the combination of death or cardiovascular hospitalization in the STICH Hypothesis 1 population (n=532) by either univariate or multivariable analysis. We were unable to identify the predictive genotypes in optimally treated patients in these two ischemic heart failure populations.
登录
查看更多内容
DOI：
10.1056/nejmoa0900559
发表时间：
2009-04-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jones RH;Velazquez EJ;Michler RE;Sopko G;Oh JK;O'Connor CM;Hill JA;Menicanti L;Sadowski Z;Desvigne-Nickens P;Rouleau JL;Lee KL;STICH Hypothesis 2 Investigators
通讯作者：
STICH Hypothesis 2 Investigators
影响因子：
9.8
作者：
Norton, Nadine;Li, Duanxiang;Hershberger, Ray E.
通讯作者：
Hershberger, Ray E.
影响因子：
8.3
作者：
Hengstenberg, C;Holmer, SR;Schunkert, H
通讯作者：
Schunkert, H
DOI：
10.1016/s0735-1097(00)00850-0
发表时间：
2000-10-01
影响因子：
24
作者：
Anderson, JL;Habashi, J;Pearson, RR
通讯作者：
Pearson, RR
影响因子：
3.9
作者：
Dorn, Gerald W., II;Liggett, Stephen B.
通讯作者：
Liggett, Stephen B.