Effects of kami-kihi-to (jia-wei-gui-pi-tang) on autoantibodies in patients with chronic immune thrombocytopenic purpura.
Effects of kami-kihi-to (jia-wei-gui-pi-tang) on autoantibodies in patients with chronic immune thrombocytopenic purpura.
复制标题
加味桂皮汤对慢性免疫性血小板减少性紫癜患者自身抗体的影响。
DOI：
10.1142/s0192415x93000297
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
K. Yasunaga
中科院分区：
文献类型：
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作者：
K. Yamaguchi;H. Kido;T. Kawakatsu;T. Fukuroi;M. Suzuki;M. Yanabu;S. Nomura;T. Kokawa;K. Yasunaga
本文研究了加味归脾汤对10例慢性免疫性血小板减少性紫癜患者自身抗体产生的影响。服用Kami-Kihi-to后，10名患者中有7名患者的血小板计数增加(p<；0.05)。经Western blotting检测，1例患者自身抗体与抗原反应消失。然而，10名患者中有8名患者的血小板相关免疫球蛋白降低(p<；0.05)。Kami-Kihi-to似乎能促进慢性免疫性血小板减少性紫癜患者自身抗体的抑制。所有患者均未观察到副作用。因此，Kami-Kihi-to可能是治疗慢性免疫性血小板减少性紫癜的一种有效且安全的药物。
We studied the effect of Kami-kihi-to (Jia-Wei-Gui-Pi-Tang) on the production of autoantibodies in ten patients with chronic immune thrombocytopenic purpura. After administration of Kami-kihi-to, platelet count was increased in seven of the ten patients (p < 0.05). Using Western blotting, we demonstrated the disappearance of autoantibody reaction with antigen in one patient. However, platelet-associated IgG was decreased in eight of ten patients (p < 0.05). Kami-kihi-to appears to promote the suppression of autoantibodies in patients with chronic immune thrombocytopenic purpura. No side effects were observed in any patient. Thus, Kami-kihi-to may be a useful and safe drug in the management of chronic immune thrombocytopenia purpura.