The control systems structures of energy metabolism
The control systems structures of energy metabolism
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DOI：
10.1098/rsif.2009.0371
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发表时间：
2010-04-06
影响因子：
3.9
通讯作者：
Wellstead, Peter
中科院分区：
文献类型：
--
作者：
Cloutier, Mathieu;Wellstead, Peter
能量代谢的生化调节(EM)允许细胞根据可用的底物和需求来调节其能量输出。为此，存在许多生物分子机制，允许感知能量状态并相应地调节酶反应速率。众所周知，这种调节会导致动态系统特性，如振荡或完全适应。虽然在实验和理论层面上已经从多个角度详细研究了能量调节的各种机制，但从控制系统的角度对EM进行系统分析还没有一个框架。在这项研究中，我们使用了众所周知的控制原理来阐明管理EM的基本系统特征。主要结果是根据广泛使用的工程控制机制细分了能量调节的生物分子机制：比例控制、积分控制、导数控制和结构：反馈、串级和前馈控制。证明了每种机制和结构的证据，并通过模拟显示了对系统属性的影响。由于这里提出的生物系统和控制组件之间的等价性是通用的，也假设我们的工作最终可能具有比当前研究重点广泛得多的适用性。
The biochemical regulation of energy metabolism (EM) allows cells to modulate their energetic output depending on available substrates and requirements. To this end, numerous biomolecular mechanisms exist that allow the sensing of the energetic state and corresponding adjustment of enzymatic reaction rates. This regulation is known to induce dynamic systems properties such as oscillations or perfect adaptation. Although the various mechanisms of energy regulation have been studied in detail from many angles at the experimental and theoretical levels, no framework is available for the systematic analysis of EM from a control systems perspective. In this study, we have used principles well known in control to clarify the basic system features that govern EM. The major result is a subdivision of the biomolecular mechanisms of energy regulation in terms of widely used engineering control mechanisms: proportional, integral, derivative control, and structures: feedback, cascade and feed-forward control. Evidence for each mechanism and structure is demonstrated and the implications for systems properties are shown through simulations. As the equivalence between biological systems and control components presented here is generic, it is also hypothesized that our work could eventually have an applicability that is much wider than the focus of the current study.