Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment
Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment
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乳腺癌细胞中 Sox2 的表达促进 M2 巨噬细胞招募至肿瘤微环境
DOI：
10.1016/j.canlet.2014.11.004
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发表时间：
2015-03-28
期刊：
影响因子：
9.7
通讯作者：
Li, Na
中科院分区：
文献类型：
--
作者：
Mou, Wenjun;Xu, Yingxi;Li, Na
转录因子Sox2促进肿瘤转移；然而，其对肿瘤相关巨噬细胞（tam， M2表型）的调节作用尚未明确。本研究揭示了tam标记物cd163与SOX2在人乳腺癌中的共同表达，并表明乳腺癌细胞中SOX2通过改变MIP-1 α、ICAM-1等多种趋化因子的表达以及Stat3和nf - κ B信号的激活，促进tam的募集。此外，tam可以挽救Sox2沉默诱导的乳腺癌细胞受损的肺转移。总之，本研究证明Sox2在募集tam中发挥重要作用，并以tam依赖的方式促进肿瘤转移。2014爱思唯尔爱尔兰有限公司版权所有。
Transcriptional factor Sox2 promotes tumor metastasis; however its regulatory effect on tumor-associated macrophages (TAMs, M2 phenotype) has not been defined. This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer and showed that Sox2 in breast cancer cells promotes recruitment of TAMs with altered expression of multiple chemokines, including MIP-1 alpha, ICAM-1 etc. and activation of Stat3 and NF-kappa B signalings. In addition, TAMs rescued the compromised lung metastasis induced by Sox2 silencing in breast cancer cells. Together, this study documented that Sox2 plays an important role in recruiting TAMs and promotes tumor metastasis in a TAMs dependent manner. (C) 2014 Elsevier Ireland Ltd. All rights reserved.