Tick-borne encephalitis virus and the immune response of the mammalian host
Tick-borne encephalitis virus and the immune response of the mammalian host
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DOI：
10.1016/j.tmaid.2010.05.010
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发表时间：
2010-07-01
影响因子：
12
通讯作者：
Hufert, Frank T.
中科院分区：
文献类型：
--
作者：
Doerrbecker, Bastian;Dobler, Gerhard;Hufert, Frank T.
蜱传脑炎（TBE）是由蜱传脑炎病毒（TBEV）引起的，这是欧洲和亚洲许多地区最流行的虫媒病毒之一。传染给人类的病毒通常通过被感染的蜱虫叮咬而发生，很少通过食用受感染牲畜的未经巴氏消毒的奶制品而发生。TBEV感染诱导先天性和适应性免疫反应，然而它能够同时在免疫系统的几种细胞类型中复制，这可能有助于病毒在人类宿主中的传播。此外，bev可以通过血脑屏障（BBB）或嗅觉神经元进入中枢神经系统（CNS），其机制尚不清楚，从而导致严重的神经系统疾病，如脑膜炎、脑炎甚至脑膜脑炎。在这篇文章中，我们回顾了已知的事实和可能的假设与TBEV与哺乳动物免疫系统的组成部分相互作用及其对TBEV介导的发病机制的影响。(C) 2010 Elsevier Ltd.版权所有。
Tick-borne encephalitis (TBE) is caused by Tick-borne encephalitis virus (TBEV), one of the most prevalent arboviruses in Europe and in many parts of Asia. Transmission of TBEV to humans usually occurs by bite of an infected tick or rarely by ingestion of unpasteurized milk products of infected livestock. TBEV infection induces an innate and adaptive immune response, nevertheless it is able to replicate in several cell types of the immune system at the same time which probably contributes to the spread of the virus in the human host. Furthermore, TBEV can enter the central nervous system (CNS) by yet not well understood mechanisms via the blood brain barrier (BBB) or the olfactory neurons which leads to serious neurological disorders like meningitis, encephalitis or even meningoencephalitis. In this article we review the known facts and possible hypotheses of interaction of TBEV with components of the mammalian immune system and their implications for TBEV-mediated pathogenesis. (C) 2010 Elsevier Ltd. All rights reserved.