Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion
Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion
复制标题
DOI：
10.1152/jappl.2000.88.1.61
复制
发表时间：
2000-01-01
影响因子：
3.3
通讯作者：
Ishii, N
中科院分区：
文献类型：
--
作者：
Takarada, Y;Nakamura, Y;Ishii, N
研究了血管闭塞的低强度耐力运动的激素和炎症反应。受试者(n=6)在坐位进行双腿伸展运动，在整个训练过程中，使用压力止血带将大腿近端压缩到214+/-7.7(SE)mm Hg。平均强度和运动量分别为1次最大重复次数的20%和14次×5次。在每一组中，受试者重复这一动作，直到筋疲力尽。分别于运动前、运动结束后及解开止血带后测定血浆生长激素(GH)、去甲肾上腺素(NE)、乳酸(La)、过氧化脂质(LP)、白介素6(IL-6)、肌酸磷酸激酶(CPK)活性。GH、NE和La的浓度在有闭塞的运动后持续出现显著的一过性升高，而在相同强度和数量的运动后，无闭塞的运动(对照)后GH、NE和La的浓度变化不大。值得注意的是，运动后15分钟，生长激素浓度达到安静水平的290倍。IL-6浓度升高更为缓慢，运动后24小时仍维持在略高于对照组的水平。LP和CPK浓度无明显变化。结果表明，极光耐力运动结合闭塞运动，通过代谢产物的局部积累，极大地刺激GH的分泌，而不会对组织造成明显的损伤。
Hormonal and inflammatory responses to low-intensity resistance exercise with vascular occlusion were studied. Subjects (n = 6) performed bilateral leg extension exercise in the seated position, with the proximal end of their thigh compressed at 214 +/- 7.7 (SE) mmHg throughout the session of exercise by means of a pressure tourniquet. Mean intensity and quantity of the exercise were 20% of 1 repetition maximum and 14 repetitions x 5 sets, respectively. In each set, the subjects repeated the movement until exhaustion. Plasma concentrations of growth hormone (GH), norepinephrine (NE), lacate (La), lipid peroxide (LP), interleukin-6 (IL-6), and activity of creatine phosphokinase (CPK) were measured before and after the exercise was finished and the tourniquet was released. Concentrations of GH, NE, and La consistently showed marked, transient increases after the exercise with occlusion, whereas they did not change a great deal after the exercise without occlusion (control) done at the same intensity and quantity. Notably, concentration of GH reached a level -290 times as high as that of the resting level 15 min after the exercise. IL-6 concentration showed a much more gradual increase and was maintained at a slightly higher level than in the control even 24 h after exercise. Concentrations of LP and CPK showed no significant change. The results suggest that extremely light resistance exercise combined with occlusion greatly stimulates the secretion of GH through regional accumulation of metabolites without considerable tissue damage.