Use of arsenic trioxide as an antivascular and thermosensitizing agent in solid tumors
Use of arsenic trioxide as an antivascular and thermosensitizing agent in solid tumors
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DOI：
10.1038/sj.neo.7900123
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发表时间：
2000-11-01
期刊：
影响因子：
4.8
通讯作者：
Song, CW
中科院分区：
文献类型：
--
作者：
Griffin, RJ;Lee, SH;Song, CW
三氧化二砷（As_2O_3，ATO）是治疗急性早幼粒细胞白血病的有效化疗药物，但其对实体瘤的作用尚未完全研究。在本报告中，我们描述了我们的观察，ATO是一种有效的抗血管剂，它显着增强对肿瘤的热疗效果。腹腔注射8 mg/kg ATO后，A/J小鼠SCK肿瘤和C3 H小鼠FSall肿瘤的血流灌注明显受到抑制，并持续24 h。作为这些效应的可能结果，ATO治疗显著增加了由41.5-42.5 ℃的高温引起的肿瘤生长延迟。肿瘤组织的免疫组织化学染色显示，全身ATO治疗后2-6小时，肿瘤中几种粘附分子和TNF α的表达水平显著增加。它的结论是，ATO是潜在的有用的，以提高在临床相关的温度对肿瘤的热疗效果。
Arsenic trioxide, As2O3 (ATO), has been found to be an effective chemotherapy drug for acute promyelocytic leukemia but its effect on solid tumors has not been fully explored. In the present report, we describe our observation that ATO is a potent antivascular agent and that it markedly enhances the effect of hyperthermia on tumors. The tumor blood perfusion in SCK tumors of A/J mice and FSall tumors of C3H mice was significantly suppressed for up to 24 hours after an i.p. injection of 8 mg/kg ATO, ATO was also found to be able to increase the thermosensitivity of tumor cells in vitro. As a probable consequence of these effects, ATO treatment markedly increased the tumor growth delay caused by hyperthermia at 41.5-42.5 degreesC. Immunohistochemical staining of tumor tissue revealed that the expression levels of several adhesion molecules and TNF alpha are noticeably increased in tumors 2-6 hours after systemic ATO treatment. It is concluded that ATO is potentially useful to enhance the effect of hyperthermia on tumors at a clinically relevant temperature.