The ribonome: a dominant force in co-ordinating gene expression.
The ribonome: a dominant force in co-ordinating gene expression.
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DOI：
10.1042/bc20080055
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发表时间：
2009-03
影响因子：
2.7
通讯作者：
Keene JD
中科院分区：
文献类型：
--
作者：
Mansfield KD;Keene JD
核糖组是细胞内RNA及其调节因子在核糖核蛋白复合物中在时间和空间上动态发挥作用的总体补充。我们推测，核糖组是一种古老的核心协调者，它一方面（前馈）在多个层面上与蛋白质组进行交流，另一方面（反馈）与转录组和RNA加工机制进行交流。此外，核糖组有可能与其他细胞进行水平交流，这对生物信息传递以及RNA和DNA操作系统的进化都有影响。共调控基因表达的转录后RNA操纵子理论解释了细胞核糖组内RNA结合蛋白的协调动力学，从而允许核糖核蛋白（RNP）的重组和重塑，以产生功能相关蛋白质的新组合。因此，转录后RNA操纵子构成了核糖组操作系统的核心，其控制和协调决定了结果。在核糖组中，RNA结合蛋白相互控制彼此的mRNA，以保持整体mRNA环境的平衡。我们认为，这些转录后的核糖组系统为组织、器官、生物体及其群落中多细胞性的进化扩展提供了一个信息管理和分配中心。
The ribonome is the total cellular complement of RNAs and their regulatory factors functioning dynamically in time and space within ribonucleoprotein complexes. We theorize that the ribonome is an ancient central co-ordinator that has evolved to communicate on multiple levels to the proteome on the one hand (feed-forward), and the transcriptome and RNA processing machinery on the other (feed-back). Furthermore, the ribonome can potentially communicate to other cells horizontally with implications for biological information transfer and for the evolution of both RNA and DNA operating systems. The post-transcriptional RNA operon theory of co-regulated gene expression accounts for the co-ordinated dynamics of RNA-binding proteins within the cellular ribonome, thus allowing for the recombination and remodelling of the RNPs (ribonucleoproteins) to generate new combinations of functionally related proteins. Thus, post-transcriptional RNA operons form the core of the ribonomic operating system in which both their control and co-ordination govern outcomes. Within the ribonome, RNA-binding proteins control one another’s mRNAs to keep the global mRNA environment in balance. We argue that these post-transcriptional ribonomic systems provide an information management and distribution centre for evolutionary expansion of multicellularity in tissues, organs, organisms, and their communities.