Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.
Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.
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来自 ATLL 流行区的患者同时出现 Epstein-Barr 病毒相关霍奇金病和成人 T 细胞白血病/淋巴瘤 (ATLL)。
DOI：
10.1016/0925-5710(95)00365-y
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发表时间：
1995
影响因子：
2.1
通讯作者：
S. Fukuhara
中科院分区：
文献类型：
--
作者：
T. Hayashi;H. Yamabe;H. Haga;T. Akasaka;N. Kadowaki;H. Ohno;M. Okuma;S. Fukuhara
我们报告了一名来自成人T细胞白血病/淋巴瘤（ATLL）流行地区的患者，他患上了具有霍奇金病（HD）特征的淋巴瘤。大型非典型Reed-Sternberg/Hodgkin细胞（RS/H细胞）具有CD3-CD15 + CD20-CD30 + CD45RO免疫表型。在RS/H细胞中检测到EB病毒（EBV）潜伏膜蛋白和EBV编码的小RNA。患者接受C-MOPP/ABVD化疗治疗HD，导致部分缓解。然而，复发发生，他死于与严重细菌感染相关的疾病进展。虽然连续淋巴结活检显示一致存在的EBV阳性RS/H细胞，背景的小淋巴细胞表现出多形性和核不规则性进行性增加。淋巴细胞具有T细胞表型，CD3 + CD4 + CD7-CD8-。使用人T细胞嗜淋巴细胞病毒-I（HTLV-I）和T细胞受体β链基因的DNA探针的Southern印迹分析证明了HTLV-I感染的单克隆T细胞随着疾病进展而扩增。我们的结论是，病人同时提出了两个独立的淋巴组织增生性疾病，EB病毒相关的HD和ATLL导致HTLV-I感染。
We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+ CD20-CD30+ CD45RO-immunophenotype. Epstein-Barr virus (EBV) latent membrane protein and EBV-encoded small RNA were detected in the RS/H cells. The patient received C-MOPP/ABVD chemotherapy for the HD resulting in a partial response. However, relapse occurred and he died of disease progression associated with serious bacterial infection. Although serial lymph node biopsies revealed consistent presence of the EBV-positive RS/H cells, the background small lymphocytes showed progressive increase in pleomorphism and nuclear irregularity. The lymphocytes had the T-cell phenotype, CD3+ CD4+ CD7-CD8-. Southern blot analysis using DNA probes for the human T-cell lymphotrophic virus-I (HTLV-I) and the T-cell receptor beta-chain gene demonstrated expansion of the HTLV-I infected monoclonal T-cells with the disease progression. We concluded that the patient synchronously presented two independent lymphoproliferative disorders; EBV-associated HD and ATLL resulting from HTLV-I infection.