Simian varicella virus infects ganglia before rash in experimentally infected monkeys
Simian varicella virus infects ganglia before rash in experimentally infected monkeys
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DOI：
10.1006/viro.2000.0700
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发表时间：
2001-01-05
期刊：
影响因子：
3.7
通讯作者：
Gilden, DH
中科院分区：
文献类型：
--
作者：
Mahalingam, R;Wellish, M;Gilden, DH
实验感染猴水痘病毒（SW）的猴子在10-14天后出现皮疹。然而，神经节感染的途径和时间尚不清楚。用PCR方法对13只猴分别经腹腔或静脉接种SW后5 ~ 60天的组织中提取的DNA进行了分析，其中5只猴在腹腔接种SW后6 ~ 7天处死，其中4只在胶质细胞中检测到SW DNA。此外，对第10天处死的猴神经节的分析表明，静脉接种产生的SW DNA阳性神经节的比例（63%）高于静脉接种后的比例（13%），这表明了在神经节感染中血源性传播的作用。与其他器官一样，猴神经节在皮疹出现之前就已被SW感染。(C)北京：科学出版社.
Monkeys experimentally infected with simian varicella virus (SW) develop rash 10-14 days later. However, the route and the time of ganglionic infection are unknown. Using PCR, we analyzed DNA extracted from tissues of 13 monkeys 5 to 60 days after either intratracheal or intravenous inoculation with SW. SW DNA was detected in gsnglia from four of five monkeys sacrificed 6 to 7 days after intratracheal inoculation. Further, analysis of ganglia from monkeys sacrificed at 10 days revealed that intravenous inoculation produced a higher proportion of SW DNA-positive gang[ia (63%) than that after intratracheal inoculation (13%), pointing to the role of hematogenous spread in ganglionic infection. Like other organs, monkey ganglia become infected with SW before the appearance of rash. (C) 2001 Academic Press.