Enhanced human memory consolidation with post-learning stress: Interaction with the degree of arousal at encoding
Enhanced human memory consolidation with post-learning stress: Interaction with the degree of arousal at encoding
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DOI：
10.1101/lm.62403
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发表时间：
2003-07-01
影响因子：
2
通讯作者：
Le, K
中科院分区：
文献类型：
--
作者：
Cahill, L;Gorski, L;Le, K
大量证据表明内源性应激激素如肾上腺素和皮质酮调节动物记忆巩固。我们最近首次证明了内源性应激激素（肾上腺素）可以增强人类记忆的巩固。然而，这些研究结果也表明，学习后应激激素激活并不能均匀地增强对所有最近获得的信息的记忆;相反，它与材料初始编码时的唤醒程度相互作用，以调节对材料的记忆。在这里，我们测试了这一假设，管理冷加压应力（CPS）或控制程序的受试者后，他们观看了不同的情绪内容的幻灯片，并评估记忆的幻灯片一周后。与对照组相比，CPS显著提高了唾液皮质醇水平，增强了对情绪激动幻灯片的记忆，但对相对中性的幻灯片没有影响。这些发现进一步支持了学习后应激相关活动与初始编码时的唤醒相互作用以调节记忆巩固的观点。
Abundant evidence indicates that endogenous stress hormones such as epinephrine and corticosterone modulate memory consolidation in animals. We recently provided the first demonstration that an endogenous stress hormone (epinephrine) can enhance human memory consolidation. However, these findings also suggested that post-learning stress hormone activation does not uniformly enhance memory for all recently acquired information; rather, that it interacts with the degree of arousal at initial encoding of material in modulating memory for the material. Here we tested this hypothesis by administering cold pressor stress (CPS) or a control procedure to subjects after they viewed slides of varying emotional content, and assessing memory for the slides I wk later. CPS, which significantly elevated salivary cortisol levels, enhanced memory for emotionally arousing slides compared with the controls, but did not affect memory for relatively neutral slides. These findings further support the view that post-learning stress hormone-related activity interacts with arousal at initial encoding to modulate memory consolidation.