The corticospinal system and transcranial magnetic stimulation in stroke.
The corticospinal system and transcranial magnetic stimulation in stroke.
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DOI：
10.1310/tsr1604-254
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发表时间：
2009-07
影响因子：
2.2
通讯作者：
Cohen LG
中科院分区：
文献类型：
--
作者：
Perez MA;Cohen LG
在过去的几十年中，经颅磁刺激（TMS）已被用作一种无创方法来研究中风后人类运动皮质重组和神经可塑性。运动控制领域越来越多的研究使用 TMS 来了解中风皮质生理学和运动恢复的不同方面。这篇综述探讨了人类和非人类灵长类动物皮质脊髓束 (CST) 损伤对运动系统功能组织的影响。我们回顾了有关生理机制的信息，通过 TMS 测量，当 CST 受伤时，CST 有助于正常运动控制和中风后中枢神经系统重组。对这些生理机制的深入了解导致了神经康复领域科学合理的介入建议的发展。
During the last decades, transcranial magnetic stimulation (TMS) has been used as a noninvasive method to investigate motor cortical reorganization and neuroplasticity in humans after stroke. An increasing number of studies in the field of motor control have used TMS to gain an understanding of the different aspects of stroke cortical physiology and motor recovery. This review addresses the effects of corticospinal tract (CST) lesions in humans and nonhuman primates on the functional organization of the motor system. We review information on the physiological mechanisms by which the CST contributes to normal motor control and to central nervous system reorganization following stroke when the CST is injured as measured using TMS. Insight into these physiological mechanisms has led to the development of scientifically sound interventional proposals in the field of neurorehabilitation.