The new era of nanotechnology, an alternative to change cancer treatment.
The new era of nanotechnology, an alternative to change cancer treatment.
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DOI：
10.2147/dddt.s142337
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Berindan-Neagoe I
中科院分区：
文献类型：
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作者：
Jurj A;Braicu C;Pop LA;Tomuleasa C;Gherman CD;Berindan-Neagoe I
在过去的几年中，纳米结构已经获得了相当大的兴趣，用于治疗剂的安全递送。已经报道了几种治疗方法，如分子诊断，疾病检测，纳米免疫治疗和抗癌药物递送，可以整合到临床使用。本文旨在强调支持使用与不同类型的治疗剂缀合的纳米颗粒的背景，适用于靶向治疗和癌症研究，特别强调血液恶性肿瘤。一个特别的关键点是非病毒递送系统的功能表征，如金纳米颗粒，脂质体和树枝状聚合物。该论文还介绍了在癌症治疗中使用纳米颗粒进行microRNA和RNA干扰递送的相关已发表数据。
In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies. A particular key point is the functional characterization of nonviral delivery systems, such as gold nanoparticles, liposomes and dendrimers. The paper also presents relevant published data related to microRNA and RNA interference delivery using nanoparticles in cancer therapy.