In Vivo Measurement of the Human Vitreous Chamber Volume Using Computed Tomography Imaging of 100 Eyes
In Vivo Measurement of the Human Vitreous Chamber Volume Using Computed Tomography Imaging of 100 Eyes
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DOI：
10.1167/tvst.9.1.2
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
Ugradar, Shoaib
中科院分区：
文献类型：
--
作者：
Azhdam, Ariel M.;Goldberg, Robert A.;Ugradar, Shoaib
目的：应用高分辨率CT扫描技术结合三维分析软件准确测量人体玻璃体体积。此外，还探讨了年龄、眼轴长度和VCV之间的潜在关系。方法：在这项回顾性研究中，对100名健康人的眼睛进行了研究。扫描是在临床护理期间获得的，没有显示任何眼眶病理的迹象。排除标准包括所有眼科病史。CT扫描层厚0.7 mm，用MIMICS图像分析软件Version 19.0进行体积分析。结果：最终样本包括50例(女性30例，男性20例)100只眼。年龄18~91岁，平均48.67±20.72岁。平均VCV女性为4.649.99±0.426.54mm3，男性为4.969.0±0.465.20 mm(3)。我们发现年龄与视神经传导速度(P<；0.001)、眼轴长度与视神经传导速度(P<；0.001)、年龄与眼轴长度(P<；0.005)显著相关。这项工作还表明，VCV与年龄和眼轴长度有关，表明它是动态的，可能会在整个成年期发生变化。翻译相关性：这一关于玻璃体体积的信息有助于我们理解我们通常插入玻璃体中的药物的适当剂量和行为。
Purpose: To accurately measure the vitreous chamber volume (VCV) in humans using high-resolution computed tomography (CT) scanning techniques combined with three-dimensional analysis software. Potential relationships between age, axial length, and VCVs were also explored.Methods: In this retrospective study, the eyes of 100 healthy individuals were studied. Scans were acquired during clinical care and did not show any signs of orbital pathology. Exclusion criteria included any ocular history. CT scans were acquired with a slice thickness of 0.7 mm, and volumetric analysis was carried out using the MIMICS image analysis software version 19.0 (Materialise, Leuven, Belgium).Results: The final sample included 100 eyes from 50 patients (30 women, 20 men). The mean age was 48.67 +/- 20.72 years, and the age range was 18 to 91 years. The mean VCV was 4.649.99 +/- 0.426.54 mm 3 for women and 4.969.0 +/- 0.465.20 mm(3) for men. We found a significant correlation between age and VCV (P < 0.001), axial length and VCV (P < 0.001), and age and axial length (P < 0.005).Conclusions: The VCV appears to be greater than the current consensus suggests. This work also suggests that the VCV is associated with age and axial length, indicating that it is dynamic and may change throughout adulthood.Translational Relevance: This information regarding the volume of the vitreous chamber is useful for our understanding of proper dosage and behavior of agents we commonly insert into the vitreous chamber.