Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma
Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma
复制标题
骨形态发生蛋白5在人肺鳞癌和腺癌中的差异表达
DOI：
10.1093/abbs/gmv037
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发表时间：
2015-07-01
影响因子：
3.7
通讯作者：
Fu, Xiangning
中科院分区：
文献类型：
--
作者：
Deng, Taoran;Lin, Dandan;Fu, Xiangning
骨形态发生蛋白（BMPs）在肿瘤细胞增殖、转移和侵袭中起重要作用。然而，骨形成蛋白在非小细胞肺癌（NSCLC）患者中的表达模式及其与NSCLC发病机制的关系尚未得到研究。在本研究中，BMP家族成员在NSCLC组织中的mRNA水平进行了分析，结果表明，BMP 5和BMP 7的mRNA水平显着下调和上调，分别在肿瘤组织与相应的非癌组织相比。有趣的是，肺腺癌组织中BMP 5的mRNA水平显著高于肺鳞癌组织。此外，免疫组化结果证实，肺腺癌中BMP 5蛋白的表达强于肺鳞癌。我们的研究结果表明，BMP 5可能是一个潜在的预后生物标志物或治疗靶点的NSCLC患者。
Bone morphogenetic proteins (BMPs) play important roles in tumor cell proliferation, metastasis, and invasion. However, the expression patterns of BMPs in patients with non-small-cell lung cancer (NSCLC) and their correlations with NSCLC pathogenesis have not been examined yet. In this study, the mRNA levels of BMP family members in NSCLC tissues were analyzed and results showed that the mRNA levels of BMP5 and BMP7 were significantly down-regulated and up-regulated, respectively, in tumor tissues compared with those in the corresponding noncancerous tissues. Interestingly, the mRNA level of BMP5 was significantly higher in lung adenocarcinoma tissues than that in lung squamous cell carcinoma tissues. Furthermore, results from immunohistochemistry analysis confirmed stronger expression of BMP5 protein in lung adenocarcinoma than in lung squamous cell carcinoma. Our findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC.