Medicinal arsenic and internal malignancies.
Medicinal arsenic and internal malignancies.
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DOI：
10.1038/bjc.1982.143
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发表时间：
1982-06
影响因子：
8.8
通讯作者：
Price Evans, D A
中科院分区：
文献类型：
--
作者：
Cuzick, J;Evans, S;Gillman, M;Price Evans, D A
对1945年至1969年期间服用福勒氏溶液（亚砷酸钾）2周至12年的一组患者进行了死亡率分析。致命性和非致命性皮肤癌的过量是显而易见的，但癌症的总体死亡率并没有过多。还提供了按癌症部位、剂量水平和首次暴露时间进行的进一步分析。在1969-70年检查了一部分患者是否存在砷性角化病、色素沉着过度和皮肤癌。大约一半的患者有一个或多个这些迹象。尽管整个亚组的癌症死亡率与预期值相似，但所有癌症死亡均发生在既往有砷中毒体征的患者中。这些数据表明，虽然由于使用Fowler溶液而导致的内部恶性肿瘤过多很少或不存在，但可能存在一个易感亚组，可以从皮肤病学表现中识别。
A mortality analysis has been carried out on a cohort of patients given Fowler's solution (potassium arsenite) for periods ranging from 2 weeks to 12 years between 1945 and 1969. An excess of fatal and non-fatal skin cancer was apparent, but there was no overall excess mortality from cancer. Further analyses by site of cancer, dose level, and time from first exposure are also presented. A subset of patients were examined in 1969-70 for the presence of arsenical keratoses, hyperpigmentation and skin cancer. About half the patients had one or more of these signs. Although the cancer mortality of this entire subgroup was similar to the expected value, all the cancer deaths occurred in patients with prior signs of arsenicism. These data suggest that while any excess of internal malignancy due to the use of Fowler's solution is small or non-existent, there may be a susceptible subgroup which can be identified from dermatological manifestations.