Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2
Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2
复制标题
DOI：
10.1016/j.ijdevneu.2009.07.006
复制
发表时间：
2009-11-01
影响因子：
1.8
通讯作者：
Taga, Tetsuya
中科院分区：
文献类型：
--
作者：
Fukushima, Mikiko;Setoguchi, Takao;Taga, Tetsuya
视网膜星形胶质细胞及其前体细胞从视神经迁移。白介素6家族细胞因子的信号转导需要gp130，可促进视神经星形胶质细胞的分化，但视网膜星形胶质细胞分化的机制尚不清楚。我们发现GFAP阳性的星形胶质细胞在数量上明显减少，但在gp130缺陷的小鼠视网膜中仍存在相当数量的星形胶质细胞。这些发现表明，依赖于gp130的信号通路在视网膜星形胶质细胞分化中起重要作用，其他信号通路也可以促进视网膜星形胶质细胞的分化。我们发现白血病抑制因子、骨形态发生蛋白及其受体在PO视网膜表达。此外，白血病抑制因子和骨形态发生蛋白2协同促进PO小鼠视网膜前体细胞向星形胶质细胞分化。这些观察表明，不仅gp130依赖的信号转导，而且骨形态发生蛋白在视网膜星形胶质细胞分化中起重要作用。(C)2009年综合业务数字网。爱思唯尔有限公司出版。保留所有权利。
Retinal astrocytes and their precursor cells migrate from the optic nerve. Interleukin 6 family cytokines, whose signal transcluction requires gp130, promote astrocyte differentiation in the optic nerve, though the mechanism of astrocyte differentiation in the retina has not been clarified. We found that GFAP-positive astrocytes were significantly decreased in number but that a considerable number of astrocytes were still present in gp130-deficient mouse retina. These findings suggest that gp130-dependent signaling pathways play essential roles in retinal astrocyte differentiation and that retinal astrocyte differentiation can also be promoted by other signaling pathways. We found that leukemia inhibitory factor, bone morphogenetic proteins, and their receptors are expressed in PO retina. In addition, leukemia inhibitory factor and bone morphogenetic protein 2 synergistically promote astrocyte differentiation of retinal precursor cells isolated from PO mouse retina. These observations demonstrated that not only gp130-dependent signaling but also bone morphogenetic proteins play essential roles in retinal astrocyte differentiation. (C) 2009 ISDN. Published by Elsevier Ltd. All rights reserved.