Heart repair and regeneration: recent insights from zebrafish studies.
Heart repair and regeneration: recent insights from zebrafish studies.
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DOI：
10.1111/j.1524-475x.2012.00814.x
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Starnes VA
中科院分区：
文献类型：
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作者：
Lien CL;Harrison MR;Tuan TL;Starnes VA
心血管疾病是美国和全世界的主要死亡原因。心肌梗死后不能正确修复或再生受损的心脏组织是心力衰竭的主要原因。与人类和其他哺乳动物不同，斑马鱼的心脏在受到严重伤害或组织损伤后可以再生。在此，我们回顾了斑马鱼心脏再生研究的最新进展，探讨了心脏三个组织层（心肌、心外膜和心内膜）的分子和细胞反应。我们还比较了用于研究斑马鱼心脏再生的不同损伤模型，并讨论了哺乳动物和斑马鱼心脏对损伤反应的差异。通过了解斑马鱼的心脏如何自然再生，我们可以更好地设计治疗策略来修复心肌梗死后的人类心脏。
Cardiovascular disease is the leading cause of death in United States and worldwide. Failure to properly repair or regenerate damaged cardiac tissues after myocardial infarction is a major cause of heart failure. In contrast to humans and other mammals, zebrafish hearts regenerate after substantial injury or tissue damage. Here, we review recent progress in studying zebrafish heart regeneration, addressing the molecular and cellular responses in the three tissue layers of the heart: myocardium, epicardium, and endocardium. We also compare different injury models utilized to study zebrafish heart regeneration, and discuss the differences in responses to injury between mammalian and zebrafish hearts. By learning how zebrafish hearts regenerate naturally, we can better design therapeutic strategies for repairing human hearts after myocardial infarction.