The developing role of receptors and adaptors
The developing role of receptors and adaptors
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DOI：
10.1038/nrc1882
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发表时间：
2006-05-01
影响因子：
78.5
通讯作者：
Mills, IG
中科院分区：
文献类型：
--
作者：
Massie, C;Mills, IG
细胞对接收到的无数信号的反应是不同的，它取决于许多不同的因素。研究最多的反应涉及生长因子信号，这些信号级联已成为癌症治疗的关键靶点。最近的报道表明，生长因子受体和相关的适配器可以在细胞核内积聚。这些蛋白质有没有新的功能，可能会影响我们对它们在癌症中的作用的理解，并对耐药性产生影响？
The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?.