Predominance of genotype A HBV in an HBV‐HIV‐1 dually positive population compared with an HIV‐1–negative counterpart in Japan
Predominance of genotype A HBV in an HBV‐HIV‐1 dually positive population compared with an HIV‐1–negative counterpart in Japan
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日本 HBV-HIV-1 双阳性人群与 HIV-1 阴性人群相比，A 基因型 HBV 占主导地位
DOI：
10.1002/jmv.1069
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发表时间：
2001
影响因子：
12.7
通讯作者：
A. Iwamoto
中科院分区：
文献类型：
--
作者：
T. Koibuchi;Akihiro Hitani;Tetsuya Nakamura;N. Nojiri;K. Nakajima;T. Jyuji;A. Iwamoto
乙型肝炎病毒（HBV）有7种基因型，从A到g。先前的研究表明，基因型C是东亚慢性HBV携带者中最常见的毒株。本研究旨在调查日本合并感染人类免疫缺陷病毒1型（HIV‐1）的患者中HBV基因型的流行病学。对18例合并感染的日本患者进行了乙型肝炎表面抗原（HBsAg）全基因序列分析。在这18名患者中，13名男男性行为者（MSM）中有12名患有基因型A(92%)，而5名异性恋或血友病患者中只有1名患有基因型A。在男男性行为者中，基因型A HBV的优势与目前日本人群中基因型的流行形成鲜明对比。由于最近日本垂直传播率的下降，性行为在乙型肝炎病毒传播中的作用不能被高估。因此，基因型A在日本的相对比例可能会逐渐增加。中华医学杂志，2004,34(4):444 - 444。©2001 Wiley‐Liss, Inc。
Hepatitis B virus (HBV) has seven genotypes, A to G. Previous studies have shown that genotype C is the most prevalent strain in chronic HBV carriers in East Asia. This study was undertaken to investigate the epidemiology of HBV genotypes among Japanese patients who are coinfected with human immunodeficiency virus type 1 (HIV‐1). The sequences of the complete hepatitis B surface antifen (HBsAg) genes were obtained from 18 coinfected Japanese patients. Among the 18 patients, 12 of 13 men who had sex with men (MSM) had genotype A (92%), whereas only one of five heterosexual or hemophiliac patients had genotype A. The predominance of genotype A HBV in MSM showed a striking contrast to the current genotype prevalence in the Japanese population. Owing to the recent decrease in the rate of vertical transmission in Japan, the role of sexual behavior in the transmission of HBV cannot be overestimated. Thus, the relative proportion of genotype A may gradually increase in Japan. J. Med. Virol. 64:435–440, 2001. © 2001 Wiley‐Liss, Inc.