Biocorrosion behavior of magnesium alloy in different simulated fluids for biomedical application
Biocorrosion behavior of magnesium alloy in different simulated fluids for biomedical application
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DOI：
10.1016/j.msec.2009.01.014
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发表时间：
2009-06-01
期刊：
影响因子：
--
通讯作者：
Zhang, Erlin
中科院分区：
文献类型：
--
作者：
Yang, Lei;Zhang, Erlin
通过电化学和失重试验研究了镁合金在两种模拟体液--Hank‘s溶液和模拟血浆(SBP)溶液中的生物腐蚀行为。通过改变溶液体积/比表面积(SV/SA)来揭示浸泡条件对生物腐蚀行为的影响。在所有试验条件下，镁合金的腐蚀速率都呈现出相同的趋势：腐蚀初期腐蚀速率较高，2-3天后腐蚀速率迅速下降，随后腐蚀速率趋于稳定。在Hank‘s溶液中，由于Hank’s溶液中高的Cl-、低的Ca~(2+)和低的PO_(43-)浓度，腐蚀速率比在SBP溶液中要高。然而，在Hank‘s溶液和SBP溶液中浸泡的样品表面反应产物没有差异。结果表明，SV/SA比对镁合金的腐蚀速率有显著影响。较低的比例导致较高的pH值，从而抵抗了腐蚀。但当比率足够高时，例如6.7，影响就可以忽略不计。通过改变比例，可以模拟镁种植体在不同种植部位的生物腐蚀行为，如在肌肉内的比例较低，在骨髓腔内的比例较高。为了模拟镁在不同植入环境下的体内生物降解行为，选择不同的模拟溶液和SV/SA比是非常必要的。(C)2009爱思唯尔B.V.保留所有权利。
The biocorrosion behavior of a magnesium alloy in two simulated body solutions, Hank's Solution and simulated blood plasma (SBP) solution was investigated by electrochemical and weight loss testing for biomedical application. The solution volume/surface area (SV/SA) ratio was changed to reveal the effect of immersion condition on the biocorrosion behavior. A same tendency was observed in the corrosion rate of magnesium alloy in all testing conditions: a high corrosion rate at the initial stage, and rapid decrease in the first 2-3 days followed by a stable corrosion rate in the following stage. A higher corrosion rate was observed in Hank's solution than in SBP solution due to high Cl-, low Ca2+ and PO43- concentration in Hank's solution. However, no difference in the surface reaction product was observed between the samples immersed in Hank's solution and in SBP solution. It was found that the SV/SA ratio significantly affected the corrosion rate of magnesium alloy. Low ratio resulted ill a high pH, which resisted the corrosion. But When the ratio was high enough, 6.7 for example, the influence was negligible. By changing the ratio, the biocorrosion behavior of magnesium implant in different implantation sites can be simulated, for example, low ratio for the case of in muscle and high ratio for the case of in marrow cavity. It is suggested that selection of the simulated solution and the SV/SA ratio would be very necessary to Simulate different the in-vivo biodegradation behavior of magnesium in different implantation environment. (C) 2009 Elsevier B.V. All rights reserved.