Serum enzymes with special reference to CK-MB following coronary bypass surgery.
Serum enzymes with special reference to CK-MB following coronary bypass surgery.
复制标题
冠状动脉搭桥手术后的血清酶，特别是 CK-MB。
DOI：
10.3109/14017437909101787
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
S. Lundberg
中科院分区：
文献类型：
--
作者：
S. Ström;R. Bendz;C. Olin;S. Lundberg
在连续 25 例冠状动脉搭桥手术中，检查了总肌酸激酶 (CK) 及其更具心脏特异性的同工酶 CK-MB 的术后血清活性水平，并将其与天冬氨酸转氨酶 (ASAT)、丙氨酸转氨酶 (ALAT) 和热稳定乳酸脱氢酶 (LD-T) 的水平、心电图 (ECG) 结果和手术特征相关联。在所有患者中都发现了可检测到的 CK-MB 活性，通常在手术仍在进行时出现。 CK-MB 峰值出现早于总 CK 峰值。任何患者均未出现心肌梗死的心电图证据。然而，术后 CK-MB 升高的程度与体外循环 (ECC) 和主动脉阻断 (AC) 的持续时间相关。经过 120 分钟的 ECC 和 70 分钟的 AC 后，CK-MB 以及所研究的其他酶的释放显着增加。高 CK-MB 活性与术后早期高总 CK、ASAT 和 LD-T 活性之间存在显着相关性。当无法测定 CK-MB 时，在术中心肌损伤的早期评估中，ASAT 优于总 CK 或 LD-T。从术后第四天开始，只有 LD-T 可以提供这方面的信息； ASAT 和 ALAT 的第二次升高可能是肝源性的。
In a consecutive series of 25 coronary bypass operations, the postoperative serum activity levels of total creatine kinase (CK) and its more heart-specific isoenzyme CK-MB were examined and related to the levels of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and thermostable lactate dehydrogenase (LD-T), to electrocardiographic (ECG) findings and to surgical characteristics. Detectable CK-MB activity was found in all patients, usually appearing while the operation was still in progress. Peak CK-MB occurred earlier than peak total CK. There was no ECG evidence of myocardial infarction in any patient. The degree of postoperative CK-MB elevation, however, correlated to the duration of extracorporeal circulation (ECC) and aortic cross-clamping (AC). After 120 min of ECC and 70 min of AC, release of CK-MB, as well as of the other enzymes studied, increased considerably. There was a significant correlation between high CK-MB activity and high early postoperative activities of total CK, ASAT and LD-T. When CK-MB determinations are not available, ASAT is preferable to total CK or LD-T in the early evaluation of operative myocardial injury. From the fourth postoperative day, only LD-T is informative in this respect; a second rise of ASAT and ALAT is probably of hepatic origin.