Ag/Cu-Mediated Decarboxylative Cyanation of Arene Carboxylic Acids Using NH_4~+/N,N-Dimethylformamide as Combined Cyanide Source
Ag/Cu-Mediated Decarboxylative Cyanation of Arene Carboxylic Acids Using NH_4~+/N,N-Dimethylformamide as Combined Cyanide Source
复制标题
以 NH_4~ /N,N-二甲基甲酰胺为联合氰源的 Ag/Cu 介导的芳烃羧酸脱羧氰化反应
DOI：
10.6023/cjoc202006031
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cai Hu
中科院分区：
文献类型：
--
作者：
Fu Zhengjiang;Hao Guangguo;Shi Quanqing;Zhou Jinqi;Jiang Ligao;Wang Shuiliang;Guo Shengmei;Cai Hu
在好氧条件下，以NH_4OAc/N，N-二甲基甲酰胺（DMF）为复合氰化源，建立了Ag/ cu介导的芳基羧酸脱羧氰化反应，并以该方法为关键步骤进一步实现了perampanel的合成。初步机理研究表明，理想产物“CN”是DMF与铵盐的结合产物。催化体系中Cu对该过程至关重要，而Ag则有利于转化。
A Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids has been well established using NH_4OAc/N,N-dimethylformamide (DMF) as a combined cyanide source under aerobic conditions, and the synthesis of perampanel was further realized with this method as the key step. Preliminary mechanistic investigation indicated the "CN" of desired products was from the combination of DMF and ammonium salt. Cu in the catalytic system was essential for the process, whereas Ag was beneficial for the transformation.