RNAi suppressors encoded by pathogenic human viruses
RNAi suppressors encoded by pathogenic human viruses
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DOI：
10.1016/j.biocel.2008.04.015
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发表时间：
2008-01-01
影响因子：
4
通讯作者：
Berkhout, Ben
中科院分区：
文献类型：
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作者：
de Vries, Walter;Berkhout, Ben
RNA 沉默或 RNAi 干扰 (RNAi) 是植物、真菌和动物的先天抗病毒机制。人类病毒与植物病毒一样，编码阻断或调节 RNAi 途径的抑制蛋白或 RNA。这篇综述总结了人类致病病毒影响 RNAi 途径的机制。此外，还讨论了病毒 RNAi 抑制功能的一些应用以及基于 RNAi 的抗病毒治疗策略的后果。 (C) 2008 Elsevier Ltd. 保留所有权利。
RNA silencing or RNAi interference (RNAi) serves as an innate antiviral mechanism in plants, fungi and animals. Human viruses, like plant viruses, encode suppressor proteins or RNAs that block or modulate the RNAi pathway. This review summarizes the mechanisms by which pathogenic human viruses affect the RNAi pathway. Furthermore, some applications of the viral RNAi suppressor functions and the consequences for antiviral therapeutic strategies that are based on RNAi are discussed. (C) 2008 Elsevier Ltd. All rights reserved.