Surface Structures and Osteoblast Activity on Biomedical Polytetrafluoroethylene Treated by Long‐Pulse, High‐Frequency Oxygen Plasma Immersion Ion Implantation
Surface Structures and Osteoblast Activity on Biomedical Polytetrafluoroethylene Treated by Long‐Pulse, High‐Frequency Oxygen Plasma Immersion Ion Implantation
复制标题
长脉冲高频氧等离子体浸没离子注入处理生物医用聚四氟乙烯的表面结构和成骨细胞活性
DOI：
10.1002/adem.201080012
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发表时间：
2010
影响因子：
3.6
通讯作者：
P. K. Chu
中科院分区：
文献类型：
--
作者：
L. Tong;D. Kwok;Huaiyu Wang;Lijun Wu;P. K. Chu
聚四氟乙烯（PTFE）是一种生物安全聚合物，广泛应用于临床医学，包括口腔和骨科手术。然而，聚四氟乙烯的高生物惰性阻碍了其在生物医学领域的广泛应用。在这项工作中，我们延长了长脉冲、高频氧等离子体浸泡离子注入PTFE的处理时间，并创造了一个水接触角为160°的超疏水表面。X射线光电子能谱（XPS）和原子力显微镜（AFM）显示，优化的长脉冲、高频氧等离子体浸没离子注入工艺使PTFE表面变得更粗糙，并且在较小程度上改变了表面氧浓度。我们的数据，特别是长期接触角，表明超疏水性源于表面粗糙度的改变。此外，在处理过的表面上培养的MC3T3‐E1成骨细胞的活性在数量和形态上都得到了提高。
Polytetrafluoroethylene (PTFE) is a biologically safe polymer used widely in clinical medicine including oral and orthopedic surgery. However, the high bio‐inertness of PTFE has hampered wider applications in the biomedical fields. In this work, we extend the treatment time in long‐pulse, high‐frequency oxygen plasma immersion ion implantation of PTFE and a more superhydrophobic surface with a water contact angle of 160° is created. X‐ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) reveal that the optimized long‐pulse, high‐frequency oxygen plasma immersion ion implantation process induces a rougher surface and to a lesser extent alters the surface oxygen concentration on the PTFE. Our data, especially long‐term contact angles, suggest that the superhydrophobility stems from surface roughness alteration. Furthermore, the activity of MC3T3‐E1 osteoblasts cultured on the treated surfaces is promoted in terms of quantities and morphology.