Inhibition-related Activation in the Right Inferior Frontal Gyrus in the Absence of Inhibitory Cues
Inhibition-related Activation in the Right Inferior Frontal Gyrus in the Absence of Inhibitory Cues
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DOI：
10.1162/jocn_a_00031
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发表时间：
2011-11-01
影响因子：
3.2
通讯作者：
Poldrack, Russell A.
中科院分区：
文献类型：
--
作者：
Lenartowicz, Agatha;Verbruggen, Frederick;Poldrack, Russell A.
右额下回（rIFG）已被假设介导反应抑制。通常，响应抑制是由外部停止提示发出的信号，它提供了一个自上而下的信号来启动该过程。然而，最近的行为研究结果表明，反应抑制也可以由自下而上的过程自动触发。在本研究中，我们评估了在自动抑制过程中是否也会观察到rIFG的活性，在自动抑制过程中，没有停止提示，也不需要实际的运动抑制。我们测量了先前与停止信号相关的刺激对rIFG激活的反应，但在当前的试验中需要反应（逆转试验）。结果显示，三角部的活动增加，表明刺激和停止之间的联系可以激活它。此外，它在抑制任务中的作用并不取决于外部停止提示的存在。我们的结论是，rIFG参与停止与行动计划重编程的作用是一致的，这可能包括抑制，它的活动可以通过自动的、自下而上的加工来触发。
The right inferior frontal gyrus (rIFG) has been hypothesized to mediate response inhibition. Typically response inhibition is signaled by an external stop cue, which provides a top-down signal to initiate the process. However, recent behavioral findings suggest that response inhibition can also be triggered automatically by bottom-up processes. In the present study, we evaluated whether rIFG activity would also be observed during automatic inhibition, in which no stop cue was presented and no motor inhibition was actually required. We measured rIFG activation in response to stimuli that were previously associated with stop signals but which required a response on the current trial (reversal trials). The results revealed an increase in rIFG (pars triangularis) activity, suggesting that it can be activated by associations between stimuli and stopping. Moreover, its role in inhibition tasks is not contingent on the presence of an external stop cue. We conclude that rIFG involvement in stopping is consistent with a role in reprogramming of action plans, which may comprise inhibition, and its activity can be triggered through automatic, bottom-up processing.