Unreliable Assessment of Necrotic Core by Virtual Histology Intravascular Ultrasound in Porcine Coronary Artery Disease
Unreliable Assessment of Necrotic Core by Virtual Histology Intravascular Ultrasound in Porcine Coronary Artery Disease
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DOI：
10.1161/circimaging.109.919357
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发表时间：
2010-07-01
影响因子：
7.5
通讯作者：
Falk, Erling
中科院分区：
文献类型：
--
作者：
Thim, Troels;Hagensen, Mette Kallestrup;Falk, Erling
血管内超声衍生的虚拟组织学（VH IVUS）越来越多地用于临床研究，以评估冠状动脉粥样硬化病变的组成和脆弱性。然而，VH IVUS量化单个斑块成分的能力，特别是不稳定坏死核心的大小，从未得到验证。我们测试了VH IVUS坏死核心大小和坏死核心大小之间的相关性，通过组织学在猪冠状动脉与人类相似coronarydiseases.Methods和Results-In成人动脉粥样硬化倾向的minipigs，18个先进的冠状动脉病变进行了评估，通过VH IVUS在体内，然后通过尸检显微镜检查（组织学）。我们发现VH IVUS确定的坏死核心的大小与组织学之间没有相关性。VH IVUS显示坏死核心病变缺乏核心histologics. Conclusions，我们发现坏死核心大小确定VH IVUS和真实的组织学之间没有相关性，质疑VH IVUS检测破裂倾向的斑块，所谓的薄帽纤维粥样硬化的能力。(Circ血管造影。2010; 3：384-391）。
Background-Intravascular ultrasound-derived virtual histology (VH IVUS) is used increasingly in clinical research to assess composition and vulnerability of coronary atherosclerotic lesions. However, the ability of VH IVUS to quantify individual plaque components, in particular the size of the destabilizing necrotic core, has never been validated. We tested for correlation between VH IVUS necrotic core size and necrotic core size by histology in porcine coronary arteries with human-like coronary disease.Methods and Results-In adult atherosclerosis-prone minipigs, 18 advanced coronary lesions were assessed by VH IVUS in vivo followed by postmortem microscopic examination (histology). We found no correlation between the size of the necrotic core determined by VH IVUS and histology. VH IVUS displayed necrotic cores in lesions lacking cores by histology.Conclusions-We found no correlation between necrotic core size determined by VH IVUS and real histology, questioning the ability of VH IVUS to detect rupture-prone plaques, so-called thin-cap fibroatheromas. (Circ Cardiovasc Imaging. 2010; 3: 384-391.)