A phospholipid uptake system in the model plant Arabidopsis thaliana
A phospholipid uptake system in the model plant Arabidopsis thaliana
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DOI：
10.1038/ncomms8649
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发表时间：
2015-07-01
影响因子：
16.6
通讯作者：
Palmgren, Michael
中科院分区：
文献类型：
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作者：
Poulsen, Lisbeth R.;Lopez-Marques, Rosa L.;Palmgren, Michael
植物利用太阳能直接从无机元素中产生脂肪，并被认为不需要分子系统从环境中吸收脂肪。在这里，我们证明了拟南芥氨基磷脂ATPase10(ALA10)是一种P4型ATPase翻转酶，它通过质膜内化外源磷脂，然后它们被快速代谢。ALA10的表达和磷脂的摄取在根尖的表皮细胞和保卫细胞中都很高，保卫细胞通过调节气孔大小来调节气体交换。ALA10基因敲除突变体表现出根尖和保卫细胞磷脂摄取减少，生长和蒸腾作用受到影响。植物中磷脂摄取系统的存在令人惊讶。我们的结果表明，这个系统的一个可能的生理作用是内化溶血磷脂酰胆碱，这是一种参与根发育和气孔控制的信号脂质。
Plants use solar energy to produce lipids directly from inorganic elements and are not thought to require molecular systems for lipid uptake from the environment. Here we show that Arabidopsis thaliana Aminophospholipid ATPase10 (ALA10) is a P4-type ATPase flippase that internalizes exogenous phospholipids across the plasma membrane, after which they are rapidly metabolized. ALA10 expression and phospholipid uptake are high in the epidermal cells of the root tip and in guard cells, the latter of which regulate the size of stomatal apertures to modulate gas exchange. ALA10-knockout mutants exhibit reduced phospholipid uptake at the root tips and guard cells and are affected in growth and transpiration. The presence of a phospholipid uptake system in plants is surprising. Our results suggest that one possible physiological role of this system is to internalize lysophosphatidylcholine, a signalling lipid involved in root development and stomatal control.