Neural changes in reward processing following approach-avoidance training for depression
Neural changes in reward processing following approach-avoidance training for depression
复制标题
抑郁症回避训练后奖励处理的神经变化
DOI：
10.1093/scan/nsab107
复制
发表时间：
2021-11-07
影响因子：
4.2
通讯作者：
Taylor, Charles
中科院分区：
文献类型：
--
作者：
Bomyea, Jessica;Choi, Soo-Hee;Taylor, Charles
改变治疗动机被认为是维持抑郁症的关键因素。计算机管理的接近避免训练项目增加了对积极刺激的接近行为倾向，产生了有益的结果。然而，很少有研究检查避近训练后的神经变化。重性抑郁障碍的参与者被随机分为两组，一组是接近-回避训练（AAT），目的是增加对积极社会线索的接近倾向（n = 13），另一组是控制程序（n = 15）。我们研究了在社会奖励预期任务（探索性）中使用群体迭代多模型估计的神经激活（主要结果）和连接模式的变化。一个基于实验室的社会关系任务也在操作之后进行，以测量在预期现实世界的社会活动期间的影响。从训练前到训练后，AAT组个体在社会奖励预期中表现出比对照组更高的奖励加工区域激活。训练结束后，在整个样本中观察到奖励区域的连接模式，内侧前额叶皮层和尾状核之间的连接与社会互动前的预期积极影响有关。两组人之间不同连接模式的初步证据也出现了。研究结果支持了一些模型，即通过计算机化训练修改方法导向的行为倾向会导致奖励回路的改变（NCT02330744）。
Altered approach motivation is hypothesized to be critical for the maintenance of depression. Computer-administered approach-avoidance training programs to increase approach action tendencies toward positive stimuli produce beneficial outcomes. However, there have been few studies examining neural changes following approach-avoidance training. Participants with major depressive disorder were randomized to an approach-avoidance training (AAT) manipulation intended to increase approach tendencies for positive social cues (n = 13) or a control procedure (n = 15). We examined changes in neural activation (primary outcome) and connectivity patterns using Group Iterative Multiple Model Estimation during a social reward anticipation task (exploratory). A laboratory-based social affiliation task was also administered following the manipulation to measure affect during anticipation of real-world social activity. Individuals in the AAT group demonstrated increased activation in reward processing regions during social reward anticipation relative to the control group from pre- to post-training. Following training, connectivity patterns across reward regions were observed in the full sample and connectivity between the medial prefrontal cortex and caudate was associated with anticipatory positive affect before the social interaction. Preliminary evidence of differential connectivity patterns between the two groups also emerged. Results support models whereby modifying approach-oriented behavioral tendencies with computerized training lead to alterations in reward circuitry (NCT02330744).