Follow-up of Card Agglutination Trypanosomiasis Test (CATT) positive but apparently aparasitaemic individuals in Cote d'Ivoire:: evidence for a complex and heterogeneous population
Follow-up of Card Agglutination Trypanosomiasis Test (CATT) positive but apparently aparasitaemic individuals in Cote d'Ivoire:: evidence for a complex and heterogeneous population
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DOI：
10.1046/j.1365-3156.2000.00623.x
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发表时间：
2000-11-01
影响因子：
3.3
通讯作者：
Büscher, P
中科院分区：
文献类型：
--
作者：
Garcia, A;Jamonneau, V;Büscher, P
人类非洲锥虫病 (HAT) 的病原学诊断基于寄生虫的检测，但目前可用的寄生虫学研究敏感性较低，并且受到寄生虫血症波动的影响。需要进行寄生虫学检查的血清阳性个体的鉴定是基于卡凝集锥虫试验 (CATT/T.b.gambiense) 的抗体检测。一个复杂的现象是出现血清学阳性但寄生虫学未经证实的结果（孤立的 CATT 阳性）。这项工作对 CATT 阳性个体进行了为期两年的纵向血清学、寄生虫学和分子随访，包括对每个个体进行回顾性检查，以研究群体和个体水平上血清阳性率随时间的演变。在人群水平上，血清阳性率在调查的头几个月内有所下降，随后表现出显着的稳定性。在个体水平上，结果揭示了该人群的极端异质性，受试者的结果存在波动，其他受试者的结果短暂短暂，而受试者则随着时间的推移保持血清阳性。血清阳性的稳定性以及免疫学和寄生虫学检查结果的模式支持这样的观点，即个体因素，例如对感染的免疫反应，可能与孤立的 CATT 阳性现象有关。
The aetiological diagnosis of human African trypanosomiasis (HAT) is based on the detection of the parasite, but currently available parasitological rests have low sensitivity and are hampered by fluctuating parasitaemia. The identification of seropositive individuals on whom to focus parasitological examination is based on antibody detection by means of the Card Agglutination Trypanosomiasi's Test (CATT/T.b.gambiense). A complicating phenomenon is the occurrence of serologically positive but parasitologically unconfirmed results (isolated CATT positivity). This work presents a two-year longitudinal serological, parasitological and molecular follow-up of CATT-positive individuals including repented examinations of each individual, to study the evolution over time of seropositivity at both the population and the individual levels. At the population level, the rate of seropositivity decreased during the first months of the survey, and afterwards showed remarkable stability At the individual level, the results reveal the extreme heterogeneity of this population, with subjects showing fluctuating results, others with a short transient CATT positivity and subjects that maintain their seropositivity over time. The stability of seropositivity and the pattern of results obtained with both immunological and parasitological examinations support the view that individual factors, such as immune response to infection, might be involved in the isolated CATT positivity phenomenon.