Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors.
Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors.
复制标题
新鉴定的斑马鱼视黄酸和类视黄醇 X 受体表达模式的比较。
DOI：
10.1002/dvdy.21049
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Yelon,Deborah
中科院分区：
文献类型：
--
作者：
Waxman,JoshuaS;Yelon,Deborah
视黄酸（RA）信号传导对于胚胎发育和组织稳态的多个方面是重要的。视黄酸受体（RAR）和类维生素A X受体（RXR）的异二聚体参与RA信号传导。目前尚不清楚受体组合的多样性如何与RA功能的多样性相关。最近报道了三种斑马鱼RAR和四种RXR的表达模式。在这里，我们确定了一个额外的RAR，一个斑马鱼RAR γ paramount，和两个额外的RXR，重复先前确定的RXR α和RXR γ。因此，斑马鱼基因组包含每个RAR和RXR基因的重复。所有的斑马鱼RAR和RXR旁系同源物都有重叠和不同的表达区域，这可能是在功能分化过程中重复基因的预期。通过代表什么是潜在的斑马鱼RAR和RXR的完整集合，本研究提供了一个有价值的参考，为未来的功能研究的个体斑马鱼RAR和RXR。发展动力学236：587-595，2007年。© 2006 Wiley利斯公司
Retinoic acid (RA) signaling is important for multiple aspects of embryonic development and tissue homeostasis. Heterodimers of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) transduce RA signaling. It is not yet clear how the diversity of receptor combinations relates to the diversity of functions for RA. The expression patterns of three zebrafish RARs and four RXRs were reported recently. Here, we identify an additional RAR, a zebrafish RARgamma paralog, and two additional RXRs, duplicates of the previously identified RXRalpha and RXRgamma. Thus, the zebrafish genome contains duplicates of each RAR and RXR gene. All zebrafish RAR and RXR paralogs have overlapping and distinct areas of expression, as might be expected for duplicate genes in the process of diverging in function. By representing what is potentially the complete set of zebrafish RARs and RXRs, this study provides a valuable reference for future functional studies of the individual zebrafish RARs and RXRs. Developmental Dynamics 236:587–595, 2007. © 2006 Wiley‐Liss, Inc.